Ascorbic acid

Chemical name

L-askorbinova acid

Gross

C6-H8-O6

Characteristics

The white crystalline powder acid taste. Easily soluble in water, soluble in alcohol.

Of drugs

Drugs, the lack of complementary vitamin C, metabolicescoe governing окислительно-восстан��вительные processes antioxidant. Drawn in thin intestine (duodenum, partly in the face). With the increase in doses up to 200 mg absorbed to 140 mg (70%); While further improving - induction decreases (50-20%); Digestive disorders (ulcers, constipation, diarrhea, morbidity invasion, E.), the use of fresh fruit and vegetable juices, drinking alkaline reduce waste askorbata in the gut. C_max after taking into achieved within 4 hours Easily penetrate leikozita, platelets, and then all fabrics; Stored in the rear share glands, Koryo napochechnikov, glaznom epitelia, intermediate cells seed glands, aicnikah, liver, brain, spleen, pancreas, lungs, kidneys, bowel wall, heart, muscles, thyroid gland. Metabolised mainly in the liver, in dezoxiaskorbinovu continue to shchavelevouxusnuu and dicketogulonovu acid. Neizmenenny askorbat and metabolites derived from urine, feces, sweat and breast milk. In higher doses, the concentration of plasma reaches more than 1.4 mg / m, down sharply increased, and increased excretion can be retained after the reception. Smoking and the use of ethanol accelerating destruction (become inactive metabolites), severely reducing the reserves Organizme.obladaet expressed antioxidant properties. Regulates transport hydrogen in many biochemical reactions, improves glucose utilization in a cycle Citric acid, has been involved in education tetragidrofolieva acid and tissue regeneration, the synthesis of steroid hormones, collagen, prokollagena. Maintained colloidal the skin substances and normal blood capillaries (gialuronidazu oppresses). Proteoliticaskie Activates enzymes involved in the exchange of aromatic amino acids, pigments and cholesterol contributes to the accumulation in the liver glycogen. The activation respiratory enzymes in the liver increases its detoksikatinuu and белковообразовательн ую the increases protrombina synthesis. Improves secretion, restores vneshnesecretornuu the pancreas and inkretornuu - thyroid. Regulates immunological reaction (activates the synthesis of antibodies, complement S_3-componenta, interferon) contributes to faguoqitozu increases resistance to infection. Assists противовоспалительно е and protiwallergicescoe effect. Release stops and accelerates degradation gistamina, oppressing education NG, etc. mediators of inflammation and arginine.

Indications

Gipovitaminoz C bloody diates, kapilliarotoxicos, haemorrhagic stroke, haemorrhage (bow, lung, uterine, etc.), infectious diseases, intoxication, and alcohol deliri infection, the acute radiation sickness, posttransfuzie complications liver disease (Hungary disease, chronic hepatitis and cirrhosis), stomach (ahilia, saying the disease, especially after the bleeding, enterita, colita, gelmintozy) holetsistit, napochechnikovaya insufficiency (Addison disease), slow healing wounds, ulcers, broken bones, malnutrition, physical and mental overload, pregnancy and lactation, gemosideros, melandermii, eritrodermii, psoriasis, chronic widespread Medicine. As an antioxidant, ulcers, bronchial asthma, a diffuse connective tissue (rheumatoid arthritis, systemic lupus red, sklerodermia), and others; Anti overdose, poisoning akonitom, anestesinom, aniline, antabusom, barbituratami, benzene, dihloretanom, potassium permanganate, metilovam alcohol, arsenic, carbon monoxide, hydrogen cyanide,, sulfanilamidami, thallium, phenols, quinine.

Contraindications

Hypersensitivity, throm, the propensity to trombozam, diabetes.

Side-Effects

Nasal irritation syndrome (nausea, vomiting, diarrhea), arterial hypertension, the metabolic functions oppression insulyarnogo apparatus pancreas (giperglikemia, glukozuria) and glycogen synthesis, reducing capillary permeability and the deterioration trophic tissue trombozitos, giperprotrombinemia, tromboobrazovanie, eritrotsitopenia, neitrofilny leucocytosis, liver diseases, damage glomerulyarnogo apparatus kidneys, allergic reactions (including anaphylactic shock); with a long reception education urinary stones, the exchange of zinc, copper, the central nervous system excitability, sleeping, mikroangiopati development.

Specific guidance

Ascorbic acid as a reducing may distort the results of the various laboratory tests (content in the blood glucose cium, transaminaz activity, LDG).

Patient interaction

Increases concentration in the blood salicilatov (increases the risk christallurii) etinilestradiola, dental and tetracycline, reducing - oral contraceptives. Decreases antikoagulyazionny effect coumarin derivatives. Improves skin in the leg iron. Increases total Cl ethanol. Anti hinolinovogo stimulants, calcium chloride, salicilata, corticosteroids in the long-term use deplete vitamin C.

Precautions

During the long-term care necessary to monitor kidney function, AD and the level of glucose (especially in the appointment of high doses).

Dosing and Administration

Inside, the food. Preventively (in the winter and spring and nepolnocennom nutrition), 50-100 mg / day (children 25 mg / day) during pregnancy and breastfeeding is 300 mg / day for 10-15 days, followed by 100 mg / day; For medicinal purposes, 100-200 mg / day (children 50-100 mg / day). 5-10% in the solutions / m and / b-1-5 ml, followed by 60 ml.

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