Folic acid

Chemical name

N-[4-[[(2-Амино-1,4-дигидро- 4-оксо-6-птеридинил)мет ил]амино]бензоил]-L-глу таминовая acid (and in the form of sodium salt)

Gross

C19-H19-N7-O6

Characteristics

Yellow or jeltovato-oranjevi crystalline powder. Virtually nerastvorim in water and alcohol, easily soluble in scheloch. Gigroskopichen. Ability to light.

Of drugs

Drugs, the lack of complementary folic acid gemopoeticescoe. Inside the converted to tetragidrofolievu acid necessary for the maturation megaloblastov and their transformation into normoblasta. When the deficit is megaloblastny blood type. Its high on the exchange purinov and pirimidinov, the synthesis of nucleic acid metabolism of amino acids (glycine, methionine and gistidina). After intake of folic acid reaction in the stomach with the domestic factor Kastla (glikoproteinom specific), absorbed in the upper gastrointestinal department bowel. Almost entirely associated with plasma proteins. Treated activate in the liver by an enzyme digidrofolatreduktaza, becoming tetragidrofolievu acid. C_max in the blood is 30 to 60 minutes. Excreted kidneys in unaltered, and in the form of metabolites.

Indications

Megaloblastnaya anaemia, spru, drug and radiation anaemia and lakopenia, postrezektinaya anaemia, chronic gastroenteritis, tuberculosis bowel insufficient folic acid.

Contraindications

Гиперчувствительност ь.

Side-Effects

Allergic reactions : bronhospazm, erythema, fever, skin rashes.

Patient interaction

Sharing with analgetikami, protivosudorojnami preparations antatidami, holestiraminom, sulfanilamidami, antibiotics reduces zitostatikami effect.

Dosing and Administration

Daily need for folic acid is for children 6 months to 25 µ g, 6-12 months-35 µ g, 1-3 years, 50 µ g, 4-6 years, 75 µ g, 7-10 years, 100 µ g, 11-14 years - 150 g, 15 years and over 200 g, for pregnant women is 400 micrograms, at the time of birth, 260-280. 2.4.3. From curative to designate the interior of the 5 mg once a day. The course of treatment 20 to 30 days.

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