Gadodiamide

Chemical name

[5,8-бис(Карбоксиметил-1 1-[2-(метиламино)-2-оксоэ тил]-3-оксо-2,5,8,11- тетраазатридекан-13-оа т]гадолиний

Gross

C16-H26-Gd-N5-O8

Characteristics

Neine connection. An aqueous solution containing 0.5 mmol (287 mg) of Volkovgeology hydrate 1 ml. Osmollnosti - 789 Mosm / kg (or 2.8 times higher osmollnosti plasma blood viscosity 1.4 (with 37 ^ C).

Of drugs

Drugs - the contrast. Increases contrast images with magnitno-rezonansnom study because Volkovgeology atoms, with paramagnitnami properties generate local magnetic field, which accelerates protons orientation surrounding water molecules, inducyruemuu magnetic field apparatus. Increases contrast images tissues facilitates visualization of abnormal structures or entity Zns.posle in / with the quick (the period of 3.7 min) goes in tissue, divided into ekstrazellliarno vnekletocna liquid. The distribution-200 61 ml / kg (equivalent to the volume of liquid vnekletocna). Linking plasma proteins have been detected. Not biotransformiroetsa. Return through the kidneys by filtering clubockova in an unmodified form. T_1/2 - 77.8 min. In 6700, following in / with the introduction in the urine detected about 85% after 24 hours was 95.4% rate. Levels of plasma and kidney Cl almost identical and were 1.7 and 1.8 ml / min, respectively. It permeates through intaknetary GEB, but violation of the permeability or disorders of cerebral circulation accumulates in pathological pockets brain and spinal cord : tumours, zones subacute stroke, abszessah et al. Changing intensity frequency Signala.v clinical optimal doses affects T_1-vzveshenne pulse sequence therefore particularly suitable for the study of the parameter tested. The largest increase was observed in the first minutes after the on / in the (depends on the type and location pathological process), the effect is to 45 minutes.

Indications

Magnitno-rezonansnaya tomography brain and spinal cord.

Contraindications

Hypersensitivity expressed violations kidney function (speed clubockova filtering less than 30 ml / min), pregnancy, breast-feeding (at some time after survey suspension), a children's age (up to 6 months).

Side-Effects

Nausea, dry mouth, loss of appetite, slavery, vomiting, abdominal pain, diarrhoea; Headache, drowsiness, anxiety, personality disorders, ataxy, coordination disorders, parestesia, tremor, convulsions until convulsant generalized attack visual impairment, the perversion and loss of taste, dizziness, weakness, a sense of fatigue; Pain, including in the chest, arthralgia, mialgii, fornication is with a sense of heat or cold, fever, vomiting, reddening of skin, the deep fear, noise in the ears, kidney failure, skin bruises, changing colour; allergic reaction, itching, urticaria, skin eritematosnye etc. skin manifestations type eritema, pershenie throat, symptoms of cardiovascular, anaphylactoidnye reaction idyoshinkrazia; asymptomatic change in the level of whey iron (via 8-48 h after); in the injection-local pain, a sense of sdavljenia.

Specific guidance

Any solution to change its colour or large particles.

Patient interaction

Farmatsevticeski incompatible with any other drugs.

Overdosing

Removed by dialysis.

Precautions

The study should be a doctor who has experience working with магнитно-резонансным�� contrasting means. Be wary when using anemiah, especially cell and hemolytic, gemoglobinopatiah, the lack of kidney and / or liver, allergic reactions (including in history). It should be borne in mind that sometimes negative results even in the presence of pathological processes (some of the differentiated malignant neoplasms and inactive times in the spread EMG not contrastnomu increase). There may be misleading colorimetric methods in the blood calcium, iron and other electrolytes, and it is not recommended to use for 12-24 h after injection. Breast-feeding resume no earlier than 24 hours after the study. During injection avoid fragmentation dose apart. Within a few hours after the procedure to monitor the condition of the patient, there is a likelihood of serious complications (anaphylacticski shock convulsing, etc.).

Dosing and Administration

In / in struino, once. Adults weighing up to 100 kg and children between 6 months, 0.2 mg / kg (0.1 mmol / kg), an adult weighing 100 kg and over-20 ml. The study started in a few minutes after the introduction and finish within 1 hour (no longer). Follow-up or studies are followed by the re-establishment of normal levels of Cl.

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