Iodixanol

Chemical name

5,5'-[(2-Гидрокси-1,3-пропа ндиил)бис(ацетилимино )]бис[N,N'-бис(2,3-дигидро��сипропил-2,4,6-трийод-1,3 -бензолдикарбоксамид]

Gross

C35-H44-I6-N6-O15

Characteristics

Nonionic dimernoe soluble yodsoderjaschee (49.1%) of the connection.

Of drugs

The drugs-rentgencontrastnoe. Provides visualization tissues in the X-ray study. 97% return with urine for 24 h, 2% via blood. The concentration of plasma maximum at the time of vnutrisosudistogo and rapidly declining (for 5-10 min), yodiksanol becomes the vnesosudistoe space. T_1/2 2 hrs healthy patients increased (up to 24 h) if there is a violation of excretory functions of the kidneys.

Indications

G : cerebral, cardiosurgery, viszeralnaya, peripheral and arterio- venografia; Urografia, X-ray computed tomography.

Contraindications

Гиперчувствительност ь (including from other yodsoderjasim drugs); chronic kidney, liver, heart failure being decompensation heavy thyrotoxicosis, dehydration, acute human liver and kidneys, pregnancy, breast-feeding (after suspending study at 2 days), children's age.

Side-Effects

The feeling of heat / cold, with the introduction, nausea, vomiting, tromboembolia, allergic reaction (itching, urticaria, erythema, swelling, anaphylaxis).

Specific guidance

The yodiksanola blood effect on the results of laboratory tests for the cium, protein, iron, calcium, phosphorus, copper.

Overdosing

There is nausea, vomiting, sossoudistam grounds, a violation of the liver, Pocek.lechenie : symptomatic; Haemodialysis removed for 6700 to 50%.

Precautions

With a history allergic diseases, asthma is premedikation antihistamines preparations glukokortikoidami. Be wary appoint older and weakened patients. Qualities can be opened only immediately before use should be carefully with the introduction of the catheter wash saline solution (to reduce the risk tromboamboliy).

Dosing and Administration

The breeding-270-320 mg / ml - producing physiological solution. For cerebral arteriografii use 5-10 ml in aortografii and urografii - 40-60 ml, and computer tomography, 50-150 ml.

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