Sodium iopodate

Chemical name

3-[[(Дим 596 етиламино)метил ен]амино]-2,4,6-трийодбе��золпропановой acid sodium salt

Gross

C12-H13-I3-N2-O-Na

Characteristics

White or slightly yellowish sheen melkochristalliceski powder.

Of drugs

The drugs-rentgencontrastnoe. Delays X rays and provides images structures containing Yod.horosho absorbed through passive diffusion through the mucous membrane of thin intestines. Selectively absorbed gepatocitami, jelchew, accumulate in the gall bladder and decreases visualisation vnepechenochnykh ERCP. Metabolised in the liver, forming rentgencontrastnye compared with glukuronova acid. Biotransformation accompanied by the release of inorganic iodine. Provided kidneys (45% within 24 h), and gastrointestinal. Most of the dose excreted within one Nedeli.maximalnaya рентгеноконтрастност ь in the 10 to 12 hours Ingibiruet making tiroxina (T_4) in triyodtironin (T_3) in the peripheral tissues and reduces the secretion of hormones the thyroid gland in gipertireoze associated with diffuse toxic goitre.

Indications

Holetsistografia, holangiografia, diffuse tireotoksicski goitre.

Contraindications

Гиперчувствительност ь (incl. to yodsoderjasim means), severe abnormalities in the liver and kidneys expressed cardiovascular diseases, Ray, pregnancy, breast-feeding (should stop breastfeeding).

Side-Effects

Diarrhoea, nausea, vomiting, heartburn, cramps in the abdomen, bloating, dizuria, acute renal failure, dizziness, headaches, anaemia, Dvs-sindrom, gipotenzia, aetiology, the acute lack koronarnaya, cardiogenny shock, cardiac arrest (in patients with ischemic heart disease), tireotoksicski kriz (with gipertireoze), education mochekislah concrements (in the background gieperriquemii) anaphylactoidnye reactions : itching, skin rash, urticaria, fever, arthralgia, shock.

Specific guidance

Admission drug effect on the results of other diagnostic studies : increasing bromsulfoftaleina delay in the liver (for a sample of 2 days after holetsistografii) reduces seizure of radioactive iodine ions as a result of one week to several months, reduces the overall T_3 and increases-and T_4 tireotroponogo hormone; increases the removal of uric acid in the urine within a few days; over a period of three days in the overall analysis of urine psevdoalbuminurija possible.

Patient interaction

Holestiramin impairs the quality of visualization of the gallbladder (breaks induction.)

Precautions

To reduce the risk anaphylactoidnykh reactions in patients with bronchial asthma and allergic diseases in the history prior to the appointment of corticosteroid and / or antigistaminnah Sredstv.neobhodimo monitor kidney function (diurez level of urea nitrogen in the blood, serum creatinine), before the holetsistografii (especially liver and kidney diseases, ks in elderly), into old age, the thyroid gland (possibly tireotoxicoza development through 4-12 weeks after contrasting X). Not recommended for use within 24 hours before or after yodipamida meglumine and means to urografii.

Dosing and Administration

Inside. Adults (weight 60-80 kg) in the dose of 3-6 G.holetsistografia : that, the night before the initial dose of a fatty food (for gallbladder removal and its contents); Designate (with warm tea) for 24 hours before the screening study, two hours after the last meal, usually evening (20 h); tucnam sick to 3 g twice : in 20 hrs and 22 hrs Between hosting preparation and study the patient should not have had (water is not limited to), smoke or use chewing gum (as it affects the irritative intestines and skin products). In 10 hours the morning of the following day, an x-ray study, and then the 45-60 minutes after breakfast jelchegng determine evaquatornuu Oxytocics and the gall bladder. In the absence of visualization gall bladder, it is possible to do an updated study on the same day, if the initial dose of 3 and Where total dose of more than 6 grams, a difference of a five days. The maximum dose of 6 g for 24 hours For children inside, 450-800 mg / Cg.holetsistoholangiografia : 3 g per 12 hours before the study or 6 g for 2 h to study (the best visualization through 1.5-2.5 h after приема).Комбинированн ая holangio- and holetsistografia : Designate in the same way as for holetsistografii, and the next morning another three grams in 1 hour a ray Issledovanie.bystraya combined holangio- and holetsistografia : Designate 6 g and 1.5 hours a holangiografiu after 3 h-holetsistografiu, If necessary, continue to dynamic Issledovanie.pri diffuse toxic zobe : 500 mg once a day.

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