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The groupAntiagreganta agregatia inhibit platelets and red and reduce their ability to seal and prilipaniu (adhesion) to endoteliu blood vessels. By lowering the surface tension of erythrocyte membranes, they facilitate their solid passing through capillaries and improve the "flow" of blood. Antiagreganta can not only prevent agregatia but a juvenile has aggregated blood gills.
Applied to the prevention of postoperative trombov in tromboflebitah, trombozah receptacles retina, human cerebral circulation et al. and for the prevention thromboembolitic complications of coronary artery disease and myocardial infarct.
Ingibirutee influence on the bonding (agregatia) platelets (and red) are to a greater or lesser degree, medicines different pharmacological groups (organic nitrates, antagonists calcium ions, derivatives purina, protivogistaminne drugs, etc.). Antiagregantnoe desire to have a non-steroidal противовоспалительны е preparations of which use for the prevention of tromboobrazovania is acetylsalicylic acid.
Acetylsalicylic acid currently is a representative antiagregantov. It has inhibitive effect on the spontaneous and inducyrovannuu agregatia and leukocyte adhesion, on the release and activation trombozitarnah factors 3 and 4. It has been shown that its antiagregazionnaya activity is closely related to the impact on the biosynthesis, liberatiou and metabolism of GHGs. It helps release endoteliem receptacles NG, including PGI_2 (prostatziklina). Last activates adenilatziklazu reduces platelets in the ionized calcium, which is one of the three major brokers aggregation and also has desagregatini activity. In addition, acetylsalicylic acid, inhibiting activity gli reduces education platelets tromboksana A_2-prostaglandina with members of the opposite type of activity (proagregazionny factor). In high doses, acetylsalicylic acid inhibits the biosynthesis prostatziklina and other antitromboticeskih prostaglandines (D_2, A_1, etc.). In this regard, as a antiagreganta azetilsalicilovu acid appointed in relatively small doses (75-325 mg / day).