Indobufen

Chemical name

({+})-4-(1,3-Дигидро-1-оксо-2 H-изоиндол-2-ил)-альфа-э тилбензолуксусная acid

Gross

C18-H17-N-O3

Of drugs

The drugs-antiagregatine, antiinflammatory, analgezirutee. Effects due to the blockade and gli tromboksancintetaza, resulting in a decreasing concentration tromboksana A-2-potent inducer of aggregation of platelets, and the relative increase in the backdrop of PGI_2 (prostatziklina); Last aguiruya adenilatziklazu in platelets, reduces the intrazellliarnogo calcium and inhibits the ability of platelets in adhesion and aggregation. The other activity similar to the established NPVS : Reduce GHG concentration in the middle of inflammation, oppression ekssoudativna coagulation and inflammation phases, reduced concentration of endogenous algogenov and reducing sensitivity to the pain receptors. Once inside quickly and completely absorbed. C_max blood achieved in 2 hours The plasma protein binds to 99%. Biotransformiroetsa in the liver with the formation of active metabolites. T_1/2 is 8 hours 75% of kidney excreted in the form of metabolites, and the active form. Effective after a single injection within 12 hours

Indications

Disease, cerebrovascular insufficiency, peripheral arteriosclerosis and cerebral receptacles throm, thrombosis deep vein, and diabetes mellitus.

Restrictions on the use of

Pregnancy, breast-feeding (at the time of treatment cease breastfeeding), children's age.

Contraindications

Hypersensitivity, allergic reactions in the history, saying the disease stomach and duodenal ulcers, Ulcerative Colitis, increased bleeding, haemophilia, bronchial asthma, emphysema lungs, heart failure, serious violations of the liver and kidneys.

Side-Effects

Gastropatia (diarrhoea phenomenon erosion and stomach ulcers, gastrointestinal bleeding), bronhospazm, oedema, increased bleeding gums, gemorroidalnah nodes varikozno expanded veins digestive, urinary tract, disruption of the liver and kidney failure and allergic reaction.

Patient interaction

Do effects and anti fibrinolitikov. Antatsida and holestiramin reduce suction.

Dosing and Administration

For adults : 200-400 mg per day in February after receiving food. Older patients lower doses twice.

Directory → Gematotropona funds → Antiagreganta → Indobufen