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Plavix

See also Clopidogrel

Roman name

Plavix

Characteristics

Rosales round dvoyakovpuklae pills Film-coated, with the engraving "1975" on one side.

Pharmacokinetics

Quickly, but incompletely absorbed from the digestive tract. Intensive metabolised in the liver, tying with plasma proteins (irreversible) - 98%. T_1/2 main circulating metabolita - inactive derivative carbolova acid-8 pm Return with urine (about 50%) and faeces (46%) for 120 h after injection.

Farmakodinamika

Selective and irreversible blockade ADF receptors trombozite prevents interaction with the mediator and suppresses the activation of GPIIb / IIIa by the action of ATP. Restoration of platelets in the course of their renewal (approximately 7 days).

Clinical pharmacology

Braking aggregation of platelets made through two hours after administration of a single dose. Repeated dose (75 mg / day) resulted in a significant decrease Adf-inducyrovanna aggregation (average fellow-40-60%) on the first day of application. Antiagregantnoe to stabilize through 3-7 days of the start of therapy and continued one hour (time updating nine), after stopping treatment.

Indications

Prevention of ailments in patients with atherosclerosis expressed, including post-myocardial infarction, stroke ishemicski or newly diagnosed disease peripheral arteries; suffering from the acute coronary syndrome recovery without ST segment (unstable stenocardia or myocardial infarction without zubza Q), in combination with acetylsalicylic acid.

Pregnancy and lactation

Assign unless it is absolutely necessary (in the absence of clinical data). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, severe liver failure, severe bleeding, such as in pepticescoy anthrax or vnutricerepnom krovoisliania.

Side-Effects

The pain in the abdomen, diarrhoea phenomenon, constipation or diarrhoea, exacerbation of ulcers stomach and duodenal ulcers; Skin rashes.

Specific guidance

In the case of surgical interventions, if antiagregatine the undesirable reception Plavixa should stop for the seven days prior to the operation.

Patient interaction

Potenziruet of acetylsalicylic acid in the коллагениндуцированн ую agregatia platelets. It increases the risk of gastrointestinal bleeding against the backdrop NPVS reception.

Precautions

Be wary appoint patients with increased risk of bleeding (injury operative intervention, etc.) and with serious kidney function and liver (perhaps the bloody diateza). Safety and effectiveness of the patients under the age of 18 years have not been established.

Storage conditions

List B. The temperature is not above 30 ° C

Shelf life

3 years

The registration

015542/01

The drug forms

Rosales round slightly 4.2.2 pills Film-coated, with the engraving "1975" on one side and "1171" on the other side. Stem pill is white.

All products of this group

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