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The groupCombined mostly slow emergence fibrina thread; They prevent tromboobrazovaniu contribute to the cessation of the growth has occurred trombov, increasing impact on phlebo fibrinoliticakih endogenous enzymes.
Combined divided into 2 groups : a) combined direct-Quick-acting (sodium heparin, nadroparin calcium enoxaparin sodium reviparin sodium, etc.), effective in vitro and in vivo; b) antiakoagulyanty proximity (antagonists vitamin C), long-acting (ethyl biskumazett, fenindion, etc.) operate only in vivo, and after a period of latency.
Antikoagulyannetary effect of heparin related to the direct effect on the blood clotting through education complexes with many factors and gemokoagulyatsii evident in the trailer I, II and III phases out. The heparin activated only in the presence of antitrombina III.
Combined indirect action derivatives oksikumarina, indandiona, competitive reduktazu inhibit vitamin K, than hinder activating last in the body longer and fusion plasma K-vitaminzawisimah hemostasis factors II, VII, IX and X.