Acenocoumarol

Chemical name

4-Гидрокси-3-[1-(4-нитроф��нил)-3-оксобутил]-2Н-1-б��нзопиран-2-он

Gross

C19-H15-N-O6

Characteristics

White or white with blue polka crystalline powder odourless. Nerastvorim in water and poorly soluble in alcohol.

Of drugs

The drugs-antikoagulyatine. Ingibiruet synthesis of vitamin K-zawisimah factors such as blood clotting (II, VII, IX, X), and thus prevents gemokoagulyatsii. After intake of fully absorbed from the digestive tract, has been associated with the plasma protein by 99%. Peak action in 24-48 hours Koumouliruet when re-admission. Following the lifting protrombinovy index (PTY) normalized 2-4 day.

Indications

Prevention and treatment trombozov, tromboflebitov, thromboembolitic complications of myocardial infarct, mertzatelna adults, etc. diseases.

Restrictions on the use of

Be wary appoint women of childbearing age (should be deleted pregnancy), older patients.

Contraindications

Gipokoagulie state (PTY less than 70%), abnormalities in the liver and kidneys, ulcerated stomach virus, neoplasticskie processes pericardit, pregnancy.

Side-Effects

Gemorragii, their probability decreases in the next row, gematuria, gingivorragia, petehii, traumatic hematoma, melena, metrorragii, gemartrozy, engjefalorragia, apoplexy; Nausea, vomiting; Alopecia, necrosis of the skin and other tissues, allergic reactions : fever, skin rashes; Brain Quick removal from the market.

Patient interaction

Effect reduce barbiturates increase-salicilata. Enhance the effectiveness of oral gipoglikemicakih funds toxicity difenina, ulzerogennosti glucocorticoids.

Dosing and Administration

Inside. On the first day, taking 8-16 mg, further reduce the dose (under the supervision PTY). Supporting dose of 1-6 mg once a day.

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