Antithrombin iii

Chemical name

Glikoprotein (alfa_2-glikoprotein with molecular weight 58,000) derived from human plasma

Characteristics

Liofilizirovanny powder purified antitrombina III human plasma. Solutions for the injections are pH 6.0-7.5.

Of drugs

The drugs-antikoagulyatine. Inactivate trombin forms with the kovalentne communication (stoichiometric 1:1), oppressing activity factor IXa, Ha, XIa, and XIIa plazmina.

Indications

Inherited deficit AT-III, Dvs-sindrom.

Contraindications

Hypersensitivity, the children's age (safety and efficacy have not been established).

Side-Effects

Dizziness, shortness or breath palpitations, nausea, bad taste in the mouth, vomiting, cramps, pain in the chest, lifted the eyes, feeling of fullness intestines, urticaria, fever, sweating, bruises.

Specific guidance

Diagnosis of hereditary deficiency AT-III shall be securely verified history patient and his relatives.

Precautions

The lower dose heparin when combined with AT-III (prevention bleeding). During pregnancy appoint unless it is absolutely necessary (security is not set).

Dosing and Administration

In / in, the dose that provides 120% of the normal level (12.5 mg / l) AT-III, given that 1 IU / kg increased plasma levels AT-III 1.4%; Supporting dose-60% of the primary every 24 hours in order to ensure the level of AT-III during long therapy in the 80% rule. The maximum daily dose is not more than 3,000 IU. Doses in international units calculated by the formula (S = (required AT-III-baseline) x weight in kg .4).

Directory → Gematotropona funds → Combined → Antithrombin iii