Fraksiparin

Roman name

Fraxiparine

Characteristics

Low heparin (NMG).

Farmakodinamika

Nadroparin calcium is higher Anti-ha factor than Anti-iia factor or antitromboticescoy activity. Relationship between the two aguostami for nadroparina within 2.5-4. The preventive doses nadroparin is expressed reduce activated partial trombinovogo time (ACTV). In kursovom treatment at the time of maximum activity ACTV may be 15.2 to the value of 1.4 times the standard. This extension reflects the residual effect antitromboticeski nadroparina calcium.

Indications

Prevention tromboobrazovania to surgical interventions, such as blood clotting in the extracorporeal blood during dialysis or gemofiltration, thromboembolitic complications in patients with a high risk of tromboobrazovania (in respiratory and / or cardiac failure in the intensive care units). Treatment tromboamboliy, unstable stenocardia and myocardial infarction without zubza Q.

Pregnancy and lactation

Experiments on animals have shown no effect tertogennogo nadroparina calcium, but in the first trimester of pregnancy preferably avoid sentencing Fraksiparina both preventive dose, and in the course of the Lechenia.v II and III trimester of pregnancy Fraksiparin can be used only on the advice of a doctor to prevent venous thrombosis (comparing benefits to the mother at risk to the foetus). Direction treatment during the same period Primenaut.esli question on the application epiduralna anaesthesia, it is recommended that, as far as possible, to suspend preventive treatment geparinom at least 12 hours before the induction Anestezii.poskolku drug in the blood of newborn babies in principle unlikely treatment Fraksiparinom breastfeeding is not contraindicated.

Contraindications

Hypersensitivity (including B19) to Fraksiparino or other NMG and / or geparino in history; Signs of bleeding or increased risk of bleeding associated with the violation of hemostasis, with the exception of putting syndrome not caused geparinom; Organic defeat of the tendency to bleeding (such as acute gastric ulcer or duodenal ulcer); injury or operational intervention CNS; endocardit Baghdad.

Side-Effects

The most frequent side effect is education subcutaneous bruising in the injection. In some cases there is a tight door, not meaning inkapsulirovanie heparin, which disappear in a few Dnei.bolshie Fraksiparina doses can cause bleeding languages available and easy trombozitopeniu (type I), which usually disappears in the process of further therapy. The temporary modest increase in liver enzymes (ALT, AST). Tuber skin and allergic reactions are rare. A few cases have been reported anaphylacticakih reactions and immune trombozitopenia (type II), combined with the blood and / or venoznam DVT or embolism.

Patient interaction

The giperkaliemii may depend on the simultaneous presence of several risk factors. Pharmaceuticals of giperkaliemia : salt, potassium kalisberegate dioretiki, ACE inhibitors, blockers receptors angiotenzina II NPVS, geparina (low or nefrackzionirovanne), and ciclosporin takrolimus, trimethoprim. The danger of giperkaliemii increases at the combination of the above tools Фраксипарином.Совмес��ное Fraksiparina use with drugs affecting gemostaz such as acetylsalicylic acid, NPVS, antagonists vitamin K, and fibrinolitiki acid leads to mutual reinforcement Effecta.krome should also be borne in mind that aggregation inhibitors nine (except for acetylsalicylic acid as a analgeticski and ingesting PP, a dose of 500 mg) : NPVS, abziksimab, acetylsalicylic acid in antiagregantnykh doses (50-300 mg) in the heart and neurological evidence beraprost, klopidogrel, eptifibatid, iloprost, tiklopidin, tirofiban increase the risk of bleeding.

Precautions

Not designed for a / m application. In connection with the possibility of resulting geparinom trombozitopenia (more on 5-21-i day treatment), it is necessary to determine the number of platelets. Be wary of patients with hepatic and / or renal failure, uncontrolled arterial hypertension, and vasculiarnah violations in vascular clad and retinal, in posleoperazionny after surgical interventions on the brain or spinal cord and eyes.

Storage conditions

List B. The temperature is not above 30 ° C

Shelf life

3 years

The registration

015872/01

The drug forms

Transparent slightly opalestiruty, colourless or light solution.

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