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Heparin

See also Heparin sodium

Roman name

Heparin

The composition and the form of

Solution for injection-5 mlgeparin sodium-25000 Mew bubbles to 5 ml; In a box 10, 50 or 100 bubbles.

Of drugs

Antikoagulyatine, fibrinoliticescoe, antiagregatine. In combination with antitrombinom III ingibiruet tromboobrazovanie by linking activated factor X and the blockade making protrombina in trombin.

Farmakodinamika

In high doses, in razvivchemsa tromboze heparin inhibits further coagulation by inactivating 821-828 and preventing fibrinoguena in fibrin. Prevents stable clots fibrina (ingibiruet activation фибрин-стабилизирующ��го factor).

Indications

Prevention and treatment trombozov and emboli, blood geparinization using apparatus artificial circulatory system (ASE) and the kidney.

Pregnancy and lactation

Perhaps only on strict conditions.

Contraindications

Heparin is not suitable for haemorrhagic diatezah (off-bleeding), and other diseases involving slow blood clotting, and increased permeability receptacles artistic methods at any location (except gemorragii / bleeding / when embolicescom infarct mild or kidney), podostrom microbial endocardite / pneumonia internal cavities of the heart / heavy human liver and kidneys, acute and chronic leikozah (malignant tumours arising from the blood cells and affects bone marrow / blood cancer), and al gipoplasticeskih anemiah (decrease in hemoglobin in the blood, because blood oppression of bone marrow), acute advanced anevrizme (highlighting wall) heart, venous gangrene.

Side-Effects

Using heparin, it is necessary to take into account the possibility of gemorragii (bleeding). To prevent complications product should be imposed only in a hospital environment (hospitals), and threatening gipokoagulyatsii (low blood coagulability) lower dose heparin (no longer intervals between injections).

Patient interaction

Gipokoagulyatsia increasing other antikoagulyantami and antiagregantami.

Overdosing

Antidote : protamine-1 mg drug per 100 IU heparin.

Dosing and Administration

Doses and use of heparin need to be customized. In acute myocardial infarct that already in the emergency rooms start (in the absence of contraindications) with the introduction of heparin in suicide in the dose of 15,000 to 20,000 U, and continue in the hospital a minimum of S -6 days of the imposition of a local unchanged at 40,000 U / day (at 5,000 to 10,000 U every 4 p). Misleading drug control blood coagulability, ensuring that the withdrawal was 2-2.5 times the norm. During the two days prior to the lifting of heparin daily dose gradually reduced (in 5000-2500 U each injection without increasing intervals wvedeniami). Since th day care has added indirect combined (neodikumarin, fenilin etc.-see page 456, 458). Following the lifting of heparin treatment continue antikoagulyantami indirect. Sometimes moving to the use of anti proximity after 3-4 days of heparin.

Storage conditions

List B. In the dark place at a temperature of 15-25 ° C

Shelf life

4

The registration

012548/01-2000

Indications for use

Applied for the prevention and therapy (treatment) of the various thromboembolitic (relating to zakuporka receptacles sgustkom blood) diseases and their complications : to prevent or limit (localization) tromboobrazovania for acute myocardial infarct, and trombozah (Education bunch blood in the cup) and emboliah (hardening of blood vessels), the main veins and arteries of the brain, eyes, from the operations in the heart and blood vessels, in order to maintain the liquid blood in the offices of artificial blood and equipment for hemodialysis (blood clearance), as well as for the prevention of blood clotting in laboratory studies.

Form of

The sealed bottle to 5 ml of activity 5000; 10,000 and 20,000 U 1 ml. Injection solution in 182,000,000 0.1 ml (1 ampoule contains 500 geparina-natria ME). Geparibene- Na C.10.4.11 -5,000. 1 spric-tubik from 0.2 ml injection solution contains : geparina-natria 5000 ME. Geparibene-ya-25 000 bottles. 1 prokalavaemy feet with 5 ml injection solution contains : geparina-natria ME 25000.

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