Heparin calcium

Chemical name

Mukopolisaharid ester poliserna acid

Of drugs

The drugs-antikoagulyatine. Forms complex with DNA antitrombina III (heparin cofactor), and the ability potenziruet inhibition of activation IX, X, XI and XII of blood coagulation. Reducing the factors hampering Ha 821-828 education and the withdrawal of blood. Makes a link trombin - antitrombin III, to prevent a fibrinoguena in fibrin and a fibrinovykh trombov. Increases lung ventilation and coronary blood, oppressing the inflammation, activates lipoproteinlipazou. After p / to the injections C_max is 30 to 60 minutes. T_1/2 - 60-90 min. It permeates through gistogematicalkie and placental barriers. Partially destroyed geparinazoy. Return with urine in an unmodified form.

Indications

Fever, tromboembolia.

Contraindications

Hypersensitivity, or bleeding tendency to bleeding (thrombocytopenia, gipofibrinogenemia, hemophilia, the vascular permeability), stomach ulcers and duodenal ulcers, acute bacterial endocardit, brain haemorrhage, posleoperazionny period with the aim brain and spinal cord.

Side-Effects

Haemorrhagic phenomenon osteoporosis (with the long-term care), an increase in the level transaminaz blood eozinofilia, thrombocytopenia, the reactions at the site of : bruises, education fridge, dermal necrosis.

Patient interaction

Antikoagulyazionny effect reinforce NPVS, including salicylic acid, tiklopidin.

Overdosing

Symptoms : Gipokoagulyatsia.lechenie : slow to / in a Protamine (antagonist).

Precautions

Be wary designate of renal and liver failure, hypertension, stomach ulcers (in history), vascular horioretinopatia, coupled with the indirect antikoagulyantami, glukokortikoidami, dekstranom in generic because of the risk of bleeding.

Dosing and Administration

P / to when tromboemboliah : 1st day 0.1 ml (2500 IU 10 kg) is the standard test dose; By 5-7 h time control on the exit Howell, which is to increase by two to three times compared to the reference; 12 h is the second injection in the same or adjusted to the dose control; in the following days, every 12 hours in the dose chosen for the second injection. Control is through 5-7 h after injection every 3-4 Dna.detam-dose Ml.prophylacticescoe use : 5,000 IU (0.2 ml) 2-3 times a day, or 7,500 IU (0.3 ml), 2 times a day, depending on body weight and degree of risk; Prevention surgery : 5000 IU (0.2 ml) for two hours before the operation, and then every 12 hours for at least 10 days.

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