Kaltsiparin

Roman name

Calciparine #

The composition and the form of

1 USD from 0.5 ml solution for injection contains calcium geparinata 12,500 IU; in the package 2 and 10 st.1 tentatively filled syringe with one dose of 0.2 ml to 5,000 IU; in the package 2 and 10 pcs.

Of drugs

The drug heparin, antikoagulyant (vehicle braking down blood) direct action. The effect of the drug is due mainly to the interaction of heparin with antitrombinom III (substance contained in the blood plasma, which prevents clot formation), which resulted in the neutralization of 821-828 (one of the factors of blood coagulability). In addition, heparin potenziruet (more) activity antitrombina III in the X factor and reduces the reaction activation of coagulation (blood clotting) with 821-828 (activation of blood clotting V, VII, XII).

Indications

Thrombosis, embolism.

Contraindications

Bleeding or propensity for bleeding related to the shortage of blood clotting (thrombocytopenia, gipofibrinogenemia / reduced in the blood fibrinoguena Vereinsbank factors hypercoagulable / haemophilia / hereditary disease in the form of increased krovotochivostyu /), and / or increased vascular permeability, except koagulopatii (type of blood coagulability) consumption; Disease accompanied by increased risk of bleeding; acute bacterial endocarditis (infection of internal cavities of the heart due to the presence in the blood of bacteria); posleoperazionny period of surgery the brain and spinal cord; bleeding in the brain; Hypersensitivity to geparino.

Side-Effects

Haemorrhagic phenomenon (bleeding), thrombocytopenia (decrease in the number of platelets in the blood), trombozitopenia associated with the blood or venoznam DVT (education bunch blood in the cup); Eozinofilia (increase in the number of Eosinophils in the blood), allergic reactions, the rising transaminaz (enzymes), osteoporosis (eating disorders bone accompanied by the increase in its friability), for long-term care. When a skin may cause hemorrhage (limited blood concentrations in the tissues / bottle).

Patient interaction

Coupled with NPVS, ticlopidine, salicylic acid and other salicilatami applied with caution.

Overdosing

There gipokoagulyaciei is neutralised slow / with the introduction of Protamine.

Precautions

Gently appoint the kidney or liver failure, hypertension, ulcers in the stomach disorder, horioretinopatia vascular, as well as in combination with indirect antikoagulyantami, glukokortikoidami, dekstranom.

Dosing and Administration

P / to when tromboemboliah : 1 day 0.1 ml (2500 IU 10 kg) is the standard test dose; By 5-7 h time control on the exit Howell (to be increased to 2-3 times as compared to the reference); 12 h is the second injection in the same dose, or adjusted according to the control; in the following days, every 12 ho a1b3 urs in the dose chosen for the second injection. Control is through 5-7 h after injection every 3-4 days. For children 0.2-0.3 ml. Prophylactic use : Standard Layout-5000 IU (0.2 ml) 2-3 times a day, or 7,500 IU (0.3 ml), 2 times a day, depending on body weight and degree of risk; Prevention surgery : Standard Layout-5000 IU (0.2 ml) for two hours before the operation, then every 12 hours for at least 10 days.

Storage conditions

r-r d / in. : List B. In cool the dark spot

Shelf life

r-r d / in. : 4.5 g.

Indications for use

Prevention and treatment of disease tromboambolicescoy (cap receptacles sgustkom blood) and trombogennah conditions (diseases, which are likely to embolic complications).

Form of

Solution intravenous sealed in 2 ml (1 ml of 5000 calziparina ME) in the package to 3 pc. ; Solution for subcutaneous injection in 182,000,000 to 1, 0.8, 0.5, 0.3 and 0.2 ml (1 ml contains 25,000 calziparina ME) in a package two pieces together with the two upper polipropilenovmi syringes. Geparibene-sa-5000 ampoules. 1 USD from 0.2 ml injection solution contains : geparina-calzia 5000 ME. Geparibene-sa-5000 C.10.4.11. 1 spric-tubik from 0.2 ml injection solution contains : geparina-calzia 5000 ME. Geparibene-sa-20 000 mg. 1 USD from 0.8 ml injection solution contains : geparina-calzia ME 20000.

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