Klexan

Roman name

Clexane

The composition and the form of

1 ml aqueous solution for subcutaneous injection contains enoksaparina 100 mg; in the ready-to-use devices to 0.2; 0.4; 0.6; 0.8 and 1.0 ml, in a cardboard package for two, or 10 pcs. (to 20; 40 and 80 mg). 1 mg enoksaparina the Anti-ha-ed 100 of the International Standard (Lmwh-nizkomolekularnah geparinov).

Pharmacokinetics

When s / to a fast and almost completely absorbed. Peak activity in the blood plasma after 40 mg achieved through three hour C_max-1.6 µ g / J T_1/2 about 4 p.m. In patients with renal insufficiency and the elderly T_1/2 more long-p 6-7, but the correction mode is not required. Anti-ha-aguosti remains in the blood for 24 hours after a single injection.

Indications

Prevention of venous trombozov and tromboamboliy (especially in orthopaedic practice, and general surgery), as well as in patients with acute therapeutic diseases in the beds; Treatment ankle deep vein; Prevent coagulation in the extracorporeal blood in the dialysis treatment fluid strokes and myocardial infarctions without zubza Q (in combination with aspirin).

Pregnancy and lactation

Only if there is strong evidence.

Contraindications

Гиперчувствительност ь to geparino and molecular analogues state with a high risk of uncontrolled bleeding, incl. peptical acute ulcers, haemorrhagic stroke.

Side-Effects

Immunoallergical thrombocytopenia (rare), the developing 5-21-i day treatment; At the beginning of therapy may experience moderate tranzitornaya asimptomatical thrombocytopenia. In the traumatic спинальной/эпидураль��ой Anaesthesia - vnutrispinalnaya bruise (rare), resulting in temporary or permanent paralysis. likely that complications may rise in the use of postoperative epidural catheter. Perhaps asimptomaticescoe and forming an increase in the number of platelets, and increased liver enzymes. In the injection-moderate red, violet, occasionally a dense inflammatory hubs Place in a few days (not require stopping treatment). Occasionally, skin or systemic allergic reactions. Bleeding under the recommended dosages are extremely rare.

Patient interaction

Prior to the appointment Klexana to cancel treatment drugs affecting gemostaz (unless they are appointed in serious condition) : NPVS (including ketorolak), and acetylsalicylic acid, acid-40, tiklopidin, systemic glukokortikoida, trombolitiki and combined.

Dosing and Administration

P / to, in the rest of peredne- or zadnelateralnuu area abdominal wall at the waist. The injection needle vertically imposed on the entire length of thick skin, knees in skladku, skladku skin was not raspravlut prior to the end of injections. After injections of the drug could not pulverize. Prevention of venous trombozov : patients with a moderate risk of tromboamboliy appoint 20 mg (0.2 ml) once a day. If the risk of tromboamboliy high dose increased to 40 mg once a day; The therapeutic sick-40 mg / day for 6-14 days. When surgery medication in the dose of 20 mg introducing two hours in advance ommuhirurgicescoy and dose of 40 mg for 12 hours before and orthopaedic surgery, and then once a day for 7 to 10 days. Length prevention may be extended as long as there is a risk of venous тромбоэмболии.Лечени�� fluid strokes and myocardial infarction (without zubza Q) for the 1 mg / kg every 12 hours until the stabilization of the patient (usually 3-8 days). Treatment evolved trombozov deep vein for the 1 mg / kg every 12 hours in or 1.5 mg / kg once a day for 10 days. The beginning oral treatment antikoagulyantami, and the introduction of enoksaparina continue to run as long as there is no effect (international normalization factor of 2 to 3). Prevention coagulation system ekstrakorporalna circulation in the kidney : Klexan introduced hypertension line at the beginning of the dialysis dose of 1 mg / kg hour procedure. For patients with a high risk of bleeding dose decreased to 0.5 mg / kg with single access. In the case of deposits fibrinovykh rings, for example, in a lengthier procedure, you can enter additional 0.5-1.0 mg / kg

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