Klivarin

Roman name

Clivarin #

The composition and the form of

Once one syringe (0.25 ml) contains 10.4 mg sodium reviparina corresponding to the unit Anti-ha-aguosti 1750 IU First international standard for nizkomolekulyarnogo heparin (equivalent to 11 to 16 mg fragment unchanged); In the box five syringes.

Characteristics

Heparin fragments with an average molecular weight of 196 mucous membrane bowel pigs received splitting with the help of nitrite.

Of drugs

Antikoagulyatine. Affects most phases out blood ingibiruet Ha-factora.

Pharmacokinetics

When s / to the introduction T_1/2 3-4 h, which is considerably higher than nefrackzionirovannogo unchanged.

Clinical pharmacology

With its ability to block Ha-factor operating on the initial drawdown and a strong and long antitrombogenny effect. The possibility of bleeding low.

Indications

Primary prevention trombozov deep vein during and after surgery; In the risk of thromboembolism.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy. Do not cross the placenta (can be administered during pregnancy), but in small quantities into the mother's milk. It can not be excluded increase the risk of miscarriage. During birth mothers receiving Klivarin, epiduralnaya anaesthesia absolutely contraindicated. In disseminirovannom vnutrisosudistom blood with koagulopatiei consumption pattern in the early otslake placenta shows an geparinom therapy and synthetic antifibrinolitikami.

Contraindications

Гиперчувствительност ь (to reviparino sodium and / or geparino), the disease is most often accompanied by high krovotochivostyu (hemorrhagic diateza, lack of blood clotting), thrombocytopenia, disease, suggesting cardiovascular disorders (stomach ulcers and / or ulcers), hypertension (diastolicescoe pressure above 105 mm Hg), haemorrhagic stroke anevrizma arteries in the brain, retinopathy, bleeding in steklovidne body.

Side-Effects

Bleeding, thrombocytopenia (including in the face of koagulopatii with venous thromboembolism and in the skin necrosis on the ground subcutaneous injection), petehii, purpura and melena, increasing whey transaminaz, LDG, lipase, giperkaliemia, gipoaldosteronizm, priapizm, vazospazm, local tissue reaction (seal skin, Depigmentation and minor bruises), allergic reaction (nausea, headache, increased body temperature, pain in the limbs, urticaria, itching, shortness of breath, bronhospazm and hypotension).

Patient interaction

Gipokoagulyatia increase derivatives solid, dipiridamol, dextran, highest antibiotics, penicillin, NPVS (acetylsalicylic acid fenilbutazon, indometacin, sulfinpirazon etc.). Nitroglycerine (in / in) may weaken effect. Propranolol, and possibly other medicinal substances removed from the compound with plasma proteins and are stronger.

Overdosing

There is a significant decrease in blood coagulability. There is a need to slow in / in a Protamine (Anti-iia-aguosti away entirely, and Anti-ha-aguosti partially) for : 1 mg Protamine 100 Anti-ha-edinic klivarina.

Precautions

A thorough medical control in the treatment of older patients, especially women, while use of medicines, increasing the level of potassium in the blood serum. Clinical experience in the treatment of children is not available. It should be avoided in / m injection because of the danger of hemorrhage. Not recommended recruit other medicinal substance in the syringe filled with molecular geparinom (formed salt and sludge with organic basis).

Dosing and Administration

P / for (it is not possible to introduce / m) : one syringe ready to be applied immediately after withdrawing the needle with a protective cap. P / injection to be made in the skin skladku abdomen (between pupkom and thoracic spine pelvis), or on the front of the thighs. Send needle vertically formed skladku skin and pull it is in a vertical direction. For primary prevention trombozov and tromboamboliy with surgical interventions first injection for two hours before the operation, and then - as in other cases. Length of the treatment depends on the nature of the disease, the risk of thrombosis and continued until 7 days. Control of platelets prior to the injections, as well as, at least, after the first and fourth days of treatment and continue twice a week.

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