Nadroparin calcium

Chemical name

Calzieva salt depolimerizovannogo unchanged with the molecular weight of 4,000 to 5,000

Characteristics

1 U nadroparina calcium with 0.41 IU Anti-ha.

Of drugs

The drugs-antikoagulyatine. And antikoagulyaim direct effect Anti-ha and Anti-iia activity has a direct impact on those in the blood coagulation factors. Do blocking effect antitrombina III factor Ha (activates transition protrombina in trombin). Anti-ha activity about four times the Anti-iia activity. And противовоспалительны ми and immunosupressivei (suppresses cooperative relationship air and B-kletok) properties, slightly lowers the level of cholesterol and beta-lipoproteidov in the serum. Improves coronary Krovotok.pri s / to the introduction C_max achieved through 3h There is a low speed link with plasma protein with little contact with the protein matrix vascular wall cells endotelia, trombozitami. Bioavailability-98%. T_1/2-3.5 hours The blockade Ha factor maintained for a period of 18-24 hours, IIa during 3h

Indications

Thrombosis of deep veins, tromboembolia pulmonary artery, acute coronary syndrome, trombozov prevention in patients at high risk : a) in orthopaedic, cancer and publehirurgicakih operations, b) the gemodialise gemofiltration and in patients with chronic renal insufficiency.

Restrictions on the use of

Arterial hypertension, posturalnaya gipotenzia, fainting, horioretinopatia, vasculita, severe kidney and liver failure expressed diabetes.

Pregnancy and lactation

Not recommended.

Contraindications

Hypersensitivity, bleeding (incl. history except koagulopatii consumption), bleeding in the brain (except systemic embolism), acute bacterial endocardit, pericardita, worsening ulcers stomach and duodenal ulcers, CNS injuries, the state of the spinal Puncture, the radiation therapy, thrombocytopenia, with a positive test aggregation in vitro in the presence of drugs, use of intra-uterine mechanical means postpartum.

Side-Effects

Thrombocytopenia, bleeding (digestive, urinary tract), bleeding (in the ovaries, a yellow body and adrenal development napochechnikova acute malnutrition), allergic reactions (fever, rash, bronchial asthma, nausea, vomiting), bruises and necrosis at the injection.

Patient interaction

Do proximity effect anticoagulants, antiagregantov, NPVS, dextran. Heart glycosides, tetratziklin, nikotinova and etakrinova acid antipruritic drugs weaken antikoagulyazionnuu activity.

Overdosing

Symptoms : Krovotechenie.lechenie : in / with the introduction of antagonist - Protamine sulfate (0.6 ml per 0.1 ml nadroparina calcium), symptomatic therapy.

Precautions

There is a need to start treatment, and then (with the long-term therapy) twice a week to count the number of blood platelets. It is a product that when the skin necrosis at the injection. The risk of bleeding in the kidney failure and women over the age of 60.

Dosing and Administration

Misleading in subcutaneous abdominal fat (needle is perpendicular dermal Llama). From curative to : two times a day for 10 days, the dose of 225 U / kg (100 IU / kg), which corresponds to : 45-55 kg 0.4-0.5 ml; 55-70 kg-brings ml; 70-80 kg-0.6-0.7 ml; 80-100 kg - 0.8 ml; more than 100 kg - 0.9 Ml.dla thromboembolitic prevent complications in surgical practice : c / to 0.3 ml for 2-4 hours before the start of the operation, and 0.3 ml once a day for the next seven days; in Orthopedic Surgery : 100 U / kg (41 IU / kg) for 12 hours before and 12 hours after the operation, the daily for 3 days, followed by 150 U / kg (61 IU / kg) 10 days. The introduction continues to the full restoration of motor activity of the patient.

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