Phenindione

Chemical name

2-Фенил-1Н-инден-1,3(2Н)-д��он

Gross

C15-H10-O2

Characteristics

White or kremovato-belae crystals. Very little soluble in water and alcohol.

Of drugs

The drugs-antikoagulyatine. Through competitive antagonism of vitamin K blocks K-vitaminreduktazu violates education in the liver its active form needed for the synthesis of protrombina and other factors out (VII, IX, X). Quickly and completely absorbed. Passes gistogematicalkie barriers and accumulates in the tissues. Metabolised in the liver. Provided kidneys (including biotransformation products). Gipokoagulyannetary effect (reduction of concentration out in the blood) is a 8-10 hrs and reaches its maximum at 24 h after administration. To monitor activity antikoagulyatini to use protrombinovogo time; Reliable prevention venous thrombosis is an increase in fuel twice and blood-3-4 times (11-14 rule c).

Indications

Prevention and treatment trombozov (especially deep vein lower limbs) and tromboflebitov, thromboembolitic complications (tromboembolia pulmonary artery embolicescie stroke, etc.) and tromboobrazovania in aftercare period; Mechanical prosthetic heart valves (regular admission), geparinoterapia (combined application).

Restrictions on the use of

Increased blood pressure, the liver and kidney, malignant neoplasms, erosivno-azwenne shock syndrome, pericardita, from the first days after birth.

Contraindications

Haemorrhagic syndrome, baseline protrombina less than 70%, pregnancy (I term).

Side-Effects

Haemorrhagic syndrome (gastrointestinal, fallopian NOSE bleeding, gematuria, bleeding in the muscle and the lung, etc.), the oppression of blood, diarrhoea disorders (diarrhea, nausea), chronic hepatitis, allergic reaction (hyperthermia, dermatitis).

Specific guidance

Therapy may be accompanied by shortness Blue in orange and urine in the color pink.

Patient interaction

Increases effects etc. combined, and tromboliticaskie antiagregaie means azathioprine, allopurinol, amiodaron, anaboliki, narcotic analgesics, androgena, antibiotics, Tricyclic antidepressants, oxidizing urine means glukokortikoida, diazoxid, dizopiramid, isoniazid, nalidiksova acid klofibrat, metronidazole, paracetamol, rezerpin solutions christalloidov, butadion, sulfanilamida, tokoferol, teturam, quinidine, ziklofosfan, zimetidin, hormones thyroid weakening - oschelacivate urine means anaprilin, antatsida, antipirin, barbiturates, vitamins K and C, haloperidol, dioretiki, carbamazepine, oral contraceptives, meprotan, rifampicin, holestiramin.

Overdosing

There haemorrhagic syndrome (gastrointestinal, fallopian NOSE bleeding, gematuria, bleeding in the skin, muscles, the lung, etc.). Treatment-vitamin C inside or / in; In the development of serious bleeding vitamin C used in / in slowly (1 mg / min) in the dose-100 mg (normalizes protrombinovoe increased during 6900). The massive hemorrhage, or in patients with liver failure at the same time apply freshfrozen plasma. Perhaps the aminocapronova acid, vitamins C and R.

Precautions

The study ED requires strict medical supervision and regular extended koagulologicescoe study blood (koagulogramma, tromboelastogramma, the number of platelets).

Dosing and Administration

Inside. In one day, a daily dose of 0.12-0.18 g 3-4 reception in the two-day 0,09-0,15 g / day, and then on 0,03-0,06 g / day 1-2 admission, depending on the content in the blood protrombina. The protrombinovogo index supported at the level of 40-60%.

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