Reviparin sodium

Chemical name

Low heparin with an average molecular mass of 196 as sodium salt

Of drugs

The drugs-antitromboticescoe, antikoagulyatine. Quickly absorbed by s / to the introduction. T_1/2, 3-4 p.m. Poor passes gistogematicalkie barriers. Do not cross the placenta (can be administered during pregnancy), in small quantities into the mother's milk. Withholding Ha-factor operating on the initial phase of the withdrawal has strong and long antitrombogenny effect, the possibility of a small bleeding (the weak antikoagulyaim operation and under normal doses does not alter the overall test-down blood). No impact on agregatia and leukocyte adhesion in the application of conventional doses.

Indications

Thrombosis deep vein, tromboembolia during and after surgery, venous thrombosis during pregnancy, thrombosis in patients on extended in the horizontal position.

Restrictions on the use of

Arterial hypertension, retinopathy, liver and / or kidney failure, pancreatitis, fresh cerebrovascular defeat, the recent rapid intervention brain trauma brain's age (clinical experience in the treatment of children is not known).

Contraindications

Hypersensitivity, thrombocytopenia, the propensity to bleeding (haemophilia, increased bleeding wounds subdural haematoma), brain damage, intracranial bleeding, surgical operations on the central nervous system, lumbale Puncture, spinalnaya or periduralnaya anaesthesia, bacterial endocardit threatening cancer, acute erosivno-azwenne shock syndrome, pregnancy (I term).

Side-Effects

Bleeding, thrombocytopenia (including, in conjunction with koagulopatiei consumption), necrosis of the skin at the injection petehii, purpura, melena, increasing whey transaminaz, LDG, lipase, giperkaliemia, gipoaldosteronizm, priapizm, vazospazm, local tissue reaction (hyperemia, Depigmentation, small bruise), allergic reaction (nausea, headache, hyperthermia, pain in the limbs, urticaria, itching, shortness of breath, bronhospazm and hypotension).

Specific guidance

Low geparina different mode of production, molecular mass, and activity is not recommended for treatment substitute one drug to others. Delivery, receipt preparation epiduralnaya anaesthesia during childbirth absolutely contraindicated.

Patient interaction

Farmatsevticeski incompatible with other drugs (forms salt and sludge with organic basis). Difenacoum solutions dextran, acetylsalicylic acid, dipiridamol, fenilbutazon, indometacin, sulfinpirazon increase the risk of bleeding. Ascorbic acid, antihistamines drugs, heart glycosides, nicotine tetratziklin, fenotiazin nitrates (injecting), penicillin reduce effectiveness.

Overdosing

Many symptoms Gipokoagulyatsii.lechenie : in / slow in introducing protamine (Anti-iia-aguosti away entirely, and Anti-ha-aguosti-part) at the rate of 1 mg Protamine 100 Anti-ha-edinic reviparina.

Precautions

A thorough medical control in the appointment of older patients, especially women, in combination with drugs that increase the level of potassium in the blood serum. It should be avoided in / m injection because of the danger of hemorrhage. During the period of treatment required leukocyte count (prior to the injection, after the first and fourth days of treatment and continue twice a week).

Dosing and Administration

P / for (in skladku skin on the abdomen between pupkom and lymph node disease or on the front of the thigh; Send needle vertically formed skladku skin and pull it is in the vertical direction). Misleading Anti-ha 1750 IU once a day for 7 to 10 days, or during the period of risk. The risk of thrombosis deep vein after the operation at tazobedrennom foot-3500 Anti-ha IU. For primary prevention trombozov and tromboamboliy with surgical interventions first injection paid 2 hours before the operation. Length of the treatment depends on the nature of the disease, the risk of thrombosis and may last up to 7 days.

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