Sulodexide

Chemical name

Глюкуроно-2-амино-2-дез оксиглюкоглюкан sulphate

Characteristics

Extract from the mucous membrane of thin intestines of pigs. Contains 80% geparinoida (moving fraction), and 20% dermatan-sulfata.

Of drugs

The drugs-antikoagulyatine, fibrinoliticescoe, antiadgezivne, angioproteguoe, gipolipidemicescoe. Suppress activity factor Ha increases prostatziklina synthesis. Decreases fibrinoguena level in plasma and stimulates fibrinoliticescuu system : increased woven activator plazminoguena reduces content in the blood of its inhibitor. Angioprotectia is rebuilding structural integrity and function endotelialnah cells, the normal density of negative charge then basal membrane endotelia. Normalizes the flow properties of the blood, reducing its viscosity, suppresses proliferatiou mezangiuma cells, reduces the thickness of basal membrane.

Indications

Angiopatii risk tromboobrazovania (including micro and macroangiopatii diabetes).

Contraindications

Hypersensitivity, bloody diates, diseases associated with increased risk of bleeding.

Side-Effects

Diarrhoeal phenomenon, nausea, vomiting, etc., as well as pain in epigastria, allergic reactions; In a place - the pain, insomnia, bruise.

Overdosing

Symptoms : bleeding or Krovotechenie.lechenie : maintaining vital functions (in the face of the drug).

Precautions

Prior to the start of treatment should be koagulogrammou. With caution in pregnancy and breastfeeding (safety and effectiveness not defined).

Dosing and Administration

Inside (between meals), in / m or / 386/1989 Therapy beginning with the daily / m of 600 LE (1 USD) for 15-20 days. Then on LE 250 twice a day for 30 days. Course to be done at least two times a year.

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