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Troparin

See also Certoparin sodium

Roman name

Troparin

The composition and the form of

1 USD from 0.5 ml or 1 spric-ampula from 0.3 ml solution for injection zertoparina contain sodium (low sodium heparin) 3000 IU antifactor Ha (approximately 1,500 IU A b920 CTV) of the mucous membrane bowel pigs with an average molecular mass of 4,000-6,000, sodium chloride, 1.69 mg (amp). , water injection to 0.5 or 0.3 ml respectively; in cartons 20 ampoules, or 5 spric-ampoul.

Pharmacokinetics

Quickly and almost completely absorbed after s / to the introduction C_max (oppression factor Ha) is 2-4 h at the dose of 1,000 IU ACTV. T_1/2 - 4h

Clinical pharmacology

Preventive action in Troparina dose of 1500 IU ACTV in a single line with 5000 IU heparin customary three times a day. Unlike nefraktingo standard heparin (a ratio antifactor Ha / ACTV 1:1), the ingibirutee Troparina a factor Ha was stronger than the effect on ACTV, which improves the efficiency ratio / portability, ie antitrombotical activity / risk of bleeding.

Indications

Embolic disease (prevention).

Pregnancy and lactation

The caution (it is not possible to avoid the risk of abortion).

Contraindications

Hypersensitivity, allergic reaction to heparin, immune thrombocytopenia genesis due geparinom (incl. history), haemophilia, trombozitopenica purpura, increased capillary permeability, stroke, severe bleeding, operational intervention at the head and spinal cord, including ophthalmic, proliferatius diabetic retinopathy, a disease hospital of stomach and duodenal ulcers, gastrointestinal bleeding, cancer of the abdomen, lung bleeding, active tuberculosis lungs, liver and pancreas, kidney, renal hemorrhage, severe arterial hypertension, bacterial endocardit threatening abortion.

Specific guidance

Designed for p / to the introduction.

Patient interaction

The effect of lower ascorbic acid, antihistamines drugs, heart glycosides, nikotinova acid and antibiotics tetratziklinove reinforce - dextran, fenilbutazon, indometacin, sulfinpirazon, probenecid, etakrinova acid (in / in), penicillin, cytostatics. Push from the blood plasma phenytoin, quinidine, propranolol and Bilirubin. Incompatible with solutions containing digidroergotamin (possible pretipitation active substance).

Precautions

Before starting on the first day and during the course of treatment necessary monitoring of blood coagulation, the number of platelets (especially between 6 and 14 day), monitoring AD. When expressed in lowering therapy platelets overturned. Suspects of the possible reactions of hypersensitivity to slow in / with a test dose (500 IU), and after a few minutes rest. The caution should be appointed to puncciah or operations spinal anesthesia after brain trombozov, diabetes, accompanied admission oral anticoagulants, in the first 36 hours after childbirth, women over 60 years of age.

Storage conditions

List B. In a cool, the dark spot

Shelf life

2

The registration

008,812 (Ann.2003, BRP)

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