Racumin nikomed

Roman name

Warfarin Nycomed

The composition and the form of

1 tablet blue round with a Kołki for division on the one hand racumin contains sodium 2.5 mg and auxiliary substances : indigodin, lactose, corn starch, povidon, gidrofosfat calcium and magnesium stearate; in polypropylene containers for 50, 100 or 250 pieces.

Characteristics

Antikoagulyant indirect action in the form of racemic compounds with levovreatmati isomer is more pharmacological activity.

Of drugs

Antikoagulyatine. Ingibiruet synthesis of vitamin K-zawisimah factors such as blood clotting (II, VII, IX, X) in the liver, reducing their concentration in plasma and to slow the process of blood clotting.

Pharmacokinetics

Extracted from the stomach almost totally. Linking blood plasma 97-99%, the concentration of therapeutic plasma 1-5 µ g / J Metabolised in the liver with the formation of inactive or low compounds that reabsorbiruyutza of bile. Report kidneys T_1/2 40 hours

Farmakodinamika

STEP is the 5th day of the application and shall cease to be in 3-5 days after lifting.

Indications

Prevention and trombozov tromboamboliy. Short-Acute tromboze veins, and pulmonary thrombo-embolism (in combination with geparinom), the post-trombose, acute myocardial infarct, and the surgical treatment tromboliticescom trombozov, a cardioversion in the case trepetania predserdy. Long-term, if retidiviruuschem tromboze veins, and pulmonary embolism artery prosthesis heart valves and receptacles (possibly in combination with acetylsalicylic acid), ischemic heart disease, tranzithornykh Cerebral attacks, the secondary prevention of heart attack, chronic atmosphere predserdy, trombose peripheral arteries.

Pregnancy and lactation

Contraindicated. For security reasons, should suspend breastfeeding in the first three days of treatment.

Contraindications

Acute bleeding expressed abnormalities in the liver and kidney failure, severe arterial hypertension, pregnancy.

Side-Effects

Liverpool (> 1%), rarely vasculit, diarrhoea, increase in liver enzymes, eczema, necrosis of the skin, hair loss.

Specific guidance

At the beginning of treatment and every 4-8 weeks should control blood coagulability in terms of personality. In combination with other drugs continuous measurement (as often as possible), to adjust racumin dose in the range of 10 to 15%.

Patient interaction

Antikoagulyannetary effect reinforce acetylsalicylic acid and other NPVS, allopurinol, amiodaron, 25.06.1997 vehicle (alkilom in regulation from 17), oral gipoglikemicakie sulfonamidnye means zefalosporin, zimetidin, danazol, diazoxid, dizopiramid, disulfiram, erythromycin, etakrinova acid flukonazol, ftorurazil, levamisole, dipiradamol, chloramphenicol, fluvoksamin, glukagon, heparin, isoniazid, ketokonazol, quinine, quinidine, hinolona, klaritromicin, klofibrat, hloralgidrat, chloramphenicol, metronidazole, miconazole, nalidiksova acid nilutamid, omeprazol, paroxetin, proguanil, simwastatin, sulfanilamida, tamoxifen, tiroksin; weaken, laxatives pills, barbiturates, dikloksacillin, fenazon, griseofulvin, carbamazepine, koenzim Q 10, kolestiramin, mianserin, Paracetamol (in high doses), retinoida, rifampicin, sukralfat, phenytoin, vitamin K (antagonist).

Overdosing

Symptoms : increased bleeding, Krovotechenia.lechenie : with considerable artistic methods in / in the slow introduction of small doses fitomendiona may receive blood transfusions.

Precautions

It is a great deal of caution in patients with endogenous human blood coagulability trombozitopenia expressed hypertension, ulcers stomach and duodenal ulcer in the process of being increased, a manifestation of the liver and kidney failure and haemorrhage in the brain, alcoholism. The consumption of alcohol increases the risk gipoprotrombinemii and bleeding.

Dosing and Administration

Inside, in a trick at the same time of day. Initial dose (1-2 days), 10 mg supporting-5-7.5 mg depending on the nature of the disease and the blood coagulability, international normalized relations (ITO) : with a mechanical prosthesis heart valves acute tromboze veins and embolism, trombose left chamber and for the prevention of a heart attack before reaching ITO (international normalized relations) 2,8-4,4. in the case of maintenance therapy with trombozah and tromboemboliah Ministry supported in the range of 2.8-3.0, in the face of acetylsalicylic acid is not a republic.

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