Aktilise

Roman name

Actilyse

Pharmacokinetics

After the on / in the rapidly distributed. T_1/2 alpha-4-5 minutes, i.e. 20 min plasma is less than 10% of the initial quantity of the drug. T_1/2 beta remaining at the depot in 40 minutes. Metabolised mainly in the liver (Cl plasma 550-680 ml / min).

Farmakodinamika

The on / in a alteplaza relatively inactive in the blood. Activated during the binding with fibrinom and induces transformation plazminoguena in plazmin by helping animals fibrinovogo bunch.

Indications

Acute myocardial infarction (first 12 hours), the acute massive tromboembolia pulmonary artery.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus (experience of pregnancy and breastfeeding limited).

Side-Effects

Bleeding : physical (from the place Puncture damaged receptacles nose, gums) and internal (in the stomach, mochepolovom intestines retroperitonealnom space, CNS, including bleeding (1%), parenchymatous organs); Already (with successful recanalization of coronary arteries in patients with acute myocardial infarction), it is rarely or holesterinova trombotical embolism, incl. kidney to the development of kidney failure, nausea, vomiting and loss of AD (can be symptoms of myocardial infarction).

Specific guidance

Aktilise ® should not be confused with other drugs (even geparinom), in general vial for infusions or katetere general.

Patient interaction

The risk of hemorrhage increases while using coumarin derivatives, antiagregantov, heparin and other drugs oppressive out blood.

Precautions

It should be borne in mind that doses above 100 mg, increasing the risk of bleeding vnutricerepnogo. The experience of the children is limited. In the event of a reaction anaphylacticescoy should stop infuziu and begin simptomaticescuu therapy.

Storage conditions

List B. In the dark place at a temperature below 25 ° C. Cooked solution, in the refrigerator up to 24 hours at a temperature not exceeding 25 ° C to 8 pm

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