Avelizin Brown

Roman name

Awelysin Braun

The composition and the form of

1 bottle with лиофилизированным powders for the preparation of injection solution contains стрептокиназы (protein with molecular weight of about 5,000 дальтон, продуцируемый certain flu strains) 100000, 250000, 750000 or 1.5 million IU; in the package 1 and 5 bottles.

Of drugs

Fibrinoliticescoe. When connected to plazminoguenom is complex aguiruty transition plazminoguena blood or blood bunch plazmin - proteoliticeski enzyme, rastvorati fibrin.

Farmakodinamika

Activates fibrinoliz by transforming profactor - plazminoguena in fibrinolizin (plazmin). Dozozawisim effect; As streptokinase is streptococcal protein with antigenic properties, it can be neutralized by antibodies; In a situation acceleration fibrinolysis is the introduction of surplus streptokinaza (for neutralizing antibodies).

Indications

Acute myocardial infarction, tromboembolia pulmonary artery and pulmonary artery tromboembolia (acute coronary peripheral arteries chronic obliteriruty endarteriit, retromboz after operations on the receptacles, obliteration arteriovenoznogo shunt); Venous thrombosis (venous thrombosis internal organs, acute thrombosis deep vein limbs and pelvis, retromboz after operations on the receptacles); coronary artery as a result of diagnostic or therapeutic procedures for children, as well as brain vessels with handling of the newborn.

Pregnancy and lactation

Contraindicated in the first 18 weeks of pregnancy, as well as in cases of complications during pregnancy and the increased risk 8818 of bleeding (predlejanie placenta, etc.). In subsequent months, pregnancy and the postpartum period (not less than 7 days) appointment is possible only by strict conditions.

Contraindications

Absolute : hypersensitivity, bleeding (including recent) bloody diates, erosivno-azwenne shock syndrome and chronic inflammatory diseases of the large bowel (including Baby Ulcerative Colitis), the recent multiple injuries anevrizma not easily treatable (refrakternaya), arterial hypertension (AD more than 200/110 mm Hg), severe diabetic retinopathy, acute pancreatitis, endocardit, mitrale heart disease with predserdy brilliance, active form of tuberculosis, etc. kavernoznae lung diseases, sepsis or septic thrombosis, posleoperazionny period (post 8-12 days, 3-6 weeks after the extended surgical interventions, 8 weeks after neurosurgical operations), 10 days after arterial punction and / m injections, four weeks after translumbalna arteriografii, three months after acute haemorrhagic stroke 3 months). Relative : transferred streptokokkova infection, such as fever (with epidemiologist antistreptokinaznah antibody more than 300 streptokinaza IU / ml), bronchial asthma expressed by the human liver and kidneys, diabetes, bronhoektaza with krovoharkanyem, veins oesophagus, neoplasms at the risk of bleeding, recent use of anticoagulants, post-cardiopulmonary resuscitation (including indirect heart massage), IVL (intubation) bleeding with chronic diseases (such as urolitiaze), chronic digestive diseases, menorragia (normal menstruation is not a contra).

Side-Effects

Bleeding from the introduction, gums, bleeding in the skin, bruises, internal bleeding (rare), reperfuzionnaya Already, necardiogenny healthy lungs, tromboembolia, kapilliarotoxicos (syndrome Shenleina - Genoha), the AST; Increase in the serum activity transaminaz, gamma-glutamiltranspeptidaza, alkaline phosphatase, kreatinkinaza, content cium, reduced cholinesterase; And allergic reactions immunopatologicakie (tide of blood to a person urticaria, skin rash, or bradi- tachycardia, falling AD, difficulty breathing, nausea, vomiting, headache, pain in the back and muscles, increased body temperature, rarely anaphylactic shock).

Specific guidance

Before the introduction of children and the sick with the disease increased subtitle antistreptokinaznah antibodies, a test sensitivity streptokinaze. The newborn and premature babies to ultrasound черепа.В early treatment инфузию should be low speed; Prior to admission and PREDNISOLONE antigistaminnah funds (prevention anaphylacticakih reactions). A periodic (every 6700) Monitoring blood coagulability : determine trombinovoe or partial tromboplastinovoe time (reoccluzii avoid pressure to increase trombinovogo time 2-4 times, and partial tromboplastinovogo at 1.5-2.5 times; it was therefore necessary to introduce a number of heparin). It should be borne in mind that the reintroduction of the drug may reduce the efficiency and increase the likelihood of collateral Actia.v the drug treatment Avelizin Brown tromboze with deep vein patients should not interrupt the reception contraceptives (high risk of intrauterine �ровотечений).Эффекти��ность product is low when it is for local intrakoronarnogo lysis for acute myocardial infarct after 12 hours in the local treatment of chronic obliterirutego endarteriita and tromboambolicescoy occluzii, after six weeks, for the treatment of systemic myocardial infarction, after 24 h, and the ankle deep vein, after 14 Dnei.s subject to the blood coagulability avoid retrombozov therapy in combination with antikoagulyantami, means shock agregatia platelets (initially heparin 500 IU / h, and then oral coumarin derivatives); in the appointment of heparin should take into account the increased risk Krovotechenia.gotove streptokinaza solutions to be used within 12 C.plazmozameshchate preparations gidroxiatilkrahmal and acid - should not be used as a solvent for the preparation Avelizin Brown because of their effects on the blood clotting.

Patient interaction

Heparin, coumarin derivatives, dipiridamol, dekstrana, acetylsalicylic acid potenziruut action of the preparation Avelizin Brown. Controlled synergies streptokinaza and acetylsalicylic acid can be used to improve trombolizisa in acute period myocardial infarction.

Overdosing

Symptoms : massive Krovotechenie.lechenie : антифибринолитически е means (or tranexamova �арааминометилбензой��ая acid inhibitors kallickreina etc. proteases such as aprotinin, in the initial dose of 500,000 CIE, then at the maintenance dose 50000-100000 CIE / h in / in drip).

Dosing and Administration

B / in (for the rapid dissolution dried Mix gently, avoiding flushing with 5 ml izotoniceski physiological solution or water for injection. The solvent may also be used 5% glucose solution ringer lactate or gelatin). Adults : for a short while lysis tromboze peripheral arteries or veins appointed primary dose of 250,000 IU for 30 minutes, then supporting dose of 1.5 million IU every hour for 6 h; maximum dose per cycle-9000000 Me.pri tromboze coronary (acute myocardial infarction), 1.5 million IU for 60 minutes, followed by heparin in the dose of 1000 IU / h. Effect control Determining trombinovoe or partial tromboplastinovoe time; Those changes are expected to be at least 2-4 or the 1,5-2,5 normal Znacheni.dl lasting lysis in tromboze peripheral vessels entering 250,000 IU for 30 minutes. Supporting dose of 100,000 IU / h. Here, a 2-4 fold increase in trombinovogo time through 6-8 h after lysis. The fibrinoguena plasma should not be lower than 1 g / O If a few hours trombinovoe increasing more than four times that supports streptokinaza dose should be increased by 2 times and applied until the trombinovogo time again stabilized in the above-mentioned Intervale.dl lysis vnutrikoronarnogo sustained through catheter impose intrakoronarno 20,000 IU, Then 2,000 IU / min for a 30-90 Min.detam : 1000-10000 IU / kg for 20-30 minutes, followed by long injection of 1000 IU / kg / h. The cease when the pulse becomes palpiruemam or when there is a significant bleeding at the site Wvedenia.dl prevention appoint retromboza гепарин.Продолжитель��ость Treatment should not exceed 5 days.

Directory → Gematotropona funds → Fibrinolitiki → Avelizin Brown