Aminocaproic acid

Chemical name

6-aminogexanova acid

Gross

C6-H13-N-O2

Characteristics

The white crystalline powder, soluble in alcohol, water, acids, nerastvorim in methanol and chloroform.

Of drugs

The drugs-gemostaticescoe. Oppressing fibrinoliz by blocking plazminoguena propellants, and plazmin. Provides system styptic effect of artistic methods of heightened activity fibrinoliticescoy plasma. In enteralnom a rapidly absorbed, C_max in plasma is 1.5 hours T_1/2-2 p.m. Report the news largely unaltered.

Indications

Status of increased activity fibrinoliticescoy blood in the cardio (including in the use of artificial apparatus circulatory), and vascular (portocavalnoe bypass) surgery, the aim of the neoplasticeskih processes in the lung, prostate gland, stomach, thyroid gland, uterus cervix, and massive gemotransfuziah.

Contraindications

Giperkoagulie state tend to tromboobrazovaniu and grounds, a breach of the kidney of cerebral circulation, Dvs-sindrom, bleeding from the upper urinary tract unknown etiology, pregnancy.

Side-Effects

Rabdomioliz, mioglobinurija, acute renal failure, subendocardiale bleeding, nausea, diarrhoea, convulsions, hypotension, headache, dizziness, noise in the ears, zalojennosti nose, skin irritation.

Patient interaction

Effect reduce combined (direct, indirect), antiagreganta.

Dosing and Administration

In / in; Acute hemorrhage within 1 h being 4-5 g dissolved in 250 ml of 0.9% solution of sodium chloride; Maintenance therapy, 1 g (50 ml) for 1 h; Infuziu continue to a complete stop bleeding, but not more than eight hours Inside appoint 5 g, and then on 1 g every hour for 8 hours (no more) to a complete stop bleeding.

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