Tranexamic acid

Chemical name

транс-4-(Аминометил)ци��логексанкарбоновая acid

Gross

C8-H15-N-O2

Characteristics

The white crystalline powder, soluble in water. An aqueous solution is pH 6.5-7.5.

Of drugs

The drugs-antifibrinoliticescoe, protiwallergicescoe, противовоспалительно е. Competitive ingibiruet plazminoguena activator, in higher concentrations, links plazmin. Lengthens trombinovoe time. Stops kininov education and other peptides involved in the inflammatory and allergic Reackziah.pri ingestion drawn 30-50% dose. C_max achieved after 3 h after administration and the dosage to 1 and 2 g of 8 and 15 mg / O Curve concentration-time is trejfaznuu form with T_1/2 the terminal phase 2 hours The blood about 3% due to protein (plazminoguenom). The initial distribution-12 litres. Easily passes through gistogematicalkie barriers, including GEB, placental. The concentration in the spinal fluid is 1 / 10 of the plasma. There are in semen, where ingibiruet fibrinoliticescuu activity, but does not affect the movement of sperm. A small portion is biotransformation. The way animal-glomeruliarnaya filtering. More than 95% (mostly unaltered) excreted in the urine. The kidney is Cl плазменному.Антифибр��нолитическая concentration in various tissues maintained for a period of 17 h, plasma until 7-8 hours

Indications

Bleeding due to the improvement of the general and local fibrinolysis (treatment and prevention) : haemophilia, hemorrhagic complications fibrinoliticescoy therapy, trombozitopenica purpura, aplastic anaemia, leukaemia, bleeding during and aftercare period breeding at birth lung, bow, jeludern-kisherne, and Bnai metrorragii, macrogematuria caused bleeding from the lower divisions mochevforodaschei system; Mouth disease, angina, laringofaringit, angioneuroticeski hereditary disorders, eczema, allergic dermatitis, urticaria, medicinal chemicals and rashes.

Contraindications

Hypersensitivity, arachnoidal bleeding, renal failure, trombofilicescie state (thrombosis deep vein, tromboamboliceski syndrome, myocardial infarction), violations of color, pregnancy.

Side-Effects

Diarrhoeal phenomenon (anorexia, nausea, vomiting, diarrhoea), dizziness, weakness, drowsiness, tachycardia, pain in the chest, gipotenzia (with the rapid on / in the introduction), the color of view, allergic skin reactions.

Patient interaction

Incompatible with urokinazoy, norarenalinom bitartratom, dezoksiepinefrinom hydrochloride, metarminom bitartratom, dipiridamolom, diazepam. The solution tranexamova acid reacts (it is not possible to mix) with antibiotics (benzylpenicillin, tetratziklin), the blood supply.

Precautions

In renal failure (depending on the serum creatinine) reduce the dose and duration of the introduction. During and after treatment for a few days to monitor ophthalmologist in verifying the severity, and fields of color, eye examinations floor. Be wary used in conjunction with fabric gemostaticakimi preparations gemokoagulaza (in high doses), geparinom. When treating kidney gematurii genesis there is a greater risk of mechanical anurii as a result of the bunch uretre.

Dosing and Administration

Inside (regardless of the meal) to 250 mg 3-4 times a day. In / in slowly, 10-15 ml. Maximum daily intake - 2 and the removal of teeth in patients with hemophilia : up to the operation at the time of substitution therapy introduced in / in the dose of 10 mg / kg; after operations inside and 25 mg / kg 3-4 times a day for 2-8 days, or inside the dose 25 mg / kg 3-4 times a day, beginning the day before the operation. Immediately prior to / for the introduction throw in the standard intravenous solutions, dextran or a solution aminocapronova acid.

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