Factor ix complex

Characteristics

Chromatographically purified fraction sterilized human plasma factor enriched phase IX.

Of drugs

The drugs-gemostaticescoe. Whereas deficiency factor out IX and eliminates gipokoagulyatia in patients with the deficit. Is the activated factor IX (Iha), and in combination with factor VIII takes the X factor in Ha, upgrades protrombina trombin in, and contributing to education fibrinovogo bunch. Increases in the level of plasma vitamin K-zawisimah coagulation factors (II, VII, IX and X). In reducing plasma levels of factor IX below 5% of sharply increased risk of spontaneous gemorragi, and the content of more than 20% of the gemostaz satisfactory. About 30-50% of factor IX is in the blood immediately after the / in Infusion; Then gemostatical activity is gradually diminishing.

Indications

Haemorrhagic syndrome, with a deficit factor IX (congenital or acquired), hemophilia B and A (monotherapy or in combination with inhibitors factor VIII), therapy kumarinovmi antikoagulyantami (incl. for injuries and operations).

Contraindications

Hypersensitivity, acute thrombosis, acute myocardial infarction, putting syndrome, the lack of factor VII, pregnancy and breast-feeding.

Side-Effects

Reducing resistance to infectious diseases, pulmonary, allergic and immunopatologicakie reactions : pain in the back, nausea, urticaria, tachycardia, arterial gipotenzia, dyspnoea, anaphylacticskie reaction; The formation of antibodies to factor IX.

Patient interaction

Incompatible with other drugs gemostaticakimi (possible contact activation or inachtiwation).

Precautions

It should be borne in mind that the resulting factor IX antibodies can be partly or wholly inachtivirovti product; And, in this case, we suggest an increase in doses and the use of activated factor protrombinovogo complex and / or immunosupressorov. When attempts a pulse slowed down or stop.

Dosing and Administration

In / in, or struino drip, not more than 2 ml / min. The batch is individually in the monitoring factor IX in the blood. In urgent cases, it should be noted that the first dose of 1 IU / kg adds factor IX at 0.5-1%, and the subsequent imposition of the same dose in the 1-1.5%. Deleting teeth and small operations of factor IX should not fall below 30% of the rules in artistic methods street below 30-50%, and the intracranial krovoislianiah or large transactions, below 60%. To prevent long hemorrhage (severe hemophilia B), 18-30 IU / kg every week, or 15 IU / kg twice a week.

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