Immunin

Roman name

Immunine #

The composition and the form of

one bottle of 5 or 10 ml of liofilizirovannam powders for the preparation of injection solution includes factors such as blood clotting IX 200, 600 or 1,200 IU, complete with water for injection in vials of five or 10 ml range supplies for plant and the introduction of (syringes and needles); in a box 21.90.

Of drugs

Gemostaticescoe. Increases the level of factor IX in the blood plasma and temporarily removes the defect closure in patients with the deficit.

Indications

Bleeding in acquired or congenital deficiency factor IX : haemophilia B, haemophilia B inhibitor factor IX gained deficit factor IX, from the advent of the inhibitor (treatment and prevention).

Pregnancy and lactation

Valid only in cases of dire need.

Contraindications

Гиперчувствительност ь.

Side-Effects

In rare cases, embolic complications (especially in patients at high risk of atherosclerosis and / or in the face of high doses. Allergic reactions (fever, urticaria, nausea, vomiting, difficulty breathing, jumps AD shock).

Specific guidance

For Infusion using single system with adequate filter. Solution must quickly absorbed rapidly and will not be used again.

Precautions

If you have allergic reactions injection (infuziu) to interrupt and begin antigistaminnuu or protivosokovu therapy. Before the surgery in patients with hemophilia B, along with Immuninom recommended low-dose heparin (prevention of thrombosis). In tromboobrazovania risk (for example, in patients with liver diseases, thrombophlebitis, stroke or myocardial infarction in history) could increase in the blood level of factor IX above 60% from the norm, there needs to be a permanent monitoring of blood coagulability as there is the risk of Dvs-sindroma (even with suspicion by the therapy should be immediately suspended).

Dosing and Administration

In / in struino or drip (speed of not more than 2 ml / min), dissolved 200-600 IU in 5 mL and 1,200 IU in 10 ml of water for injection, immediately before the introduction. To evaluate the effectiveness of therapy and for the required maintenance dose determine the factor IX blood plasma, and use formula-dose (IU) = weight (kg) x desired increase factor IX (%) x 1.2. Misleading Immunin every 24 hours; For the maintenance treatment of severe hemophilia B is 20-30 IU / kg twice a week; For the prevention of bleeding in surgical operations, for one hour before the operation; After major intervention every 12h (during the first postoperative day).

Storage conditions

por.liof.d / in. : List B. The temperature of 2-8 ° C

Shelf life

por.liof.d / in. : 2 city. (3 months-at room temperature no higher than 25 ° C).

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