Menadione sodium bisulfite

Chemical name

2-Метил-1,4-нафталендио�� sodium sulfonat

Gross

C11-H9-Na-O5-S

Of drugs

The drugs-gemostaticescoe. Increases coagulation of blood through the strengthening of the liver factors II, VII, IX and X. The effect is manifested in 12 to 18 hours after the / m introduction. The blood protrombin (factor II) in the presence of tromboplastina and calcium ions, with the participation of prokonvertina (factor VII), of IX and X goes into trombin, under the influence of fibrinogen which turns into fibrin of the blood volume (brain). In the absence of vitamin C, a synthetic gomologom is menadion arises increased bleeding. Substratno stimulates K-vitaminreduktazu, aguirutuyu vitamin K and ensure his participation in the synthesis of pechenernm K-vitaminzawisimah plasma factors hemostasis. After the / m of easily and rapidly absorbed. After cycle metabolic activation oxidized to diolova forms. Report the news.

Indications

Haemorrhaging (bleeding) in the face of gipoprotrombinemii : obturazionnaya jaundice, hepatitis, and lung haemorrhage Lully with injuries, surgery, disease and radiation sickness; Gemorroidale, uterine, lung and long bow bleeding; Hemorrhagic phenomena of weight; Neodikumarina overdose, etc. anti proximity.

Contraindications

Hypersensitivity, giperkoagulyatsia, tromboembolia, haemolytic disease of newborns.

Side-Effects

Hemolytic anemia, giperbilirubinemia, jaundice, especially premature, gemoliz in infants with congenital deficiency глюкозо-6-фосфатдегид��огеназы.

Patient interaction

Ters indirect effects anticoagulants.

Dosing and Administration

V / m. Misleading on 0,01-0,015 g once a day for 3-4 days, a 4-day repeat cycle. When surgical intervention with the possibility of heavy bleeding parenhimatoznam appointed for a period of two to three days before the operation. Higher doses (in / m) : single-0.015 g daily, 0.03 inside the city, adults on 15-30 mg per day, children 2-15 mg / day, depending on age.

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