Protamine sulfate

Characteristics

White fine, or it is not white amorphous or crystalline powder sparingly soluble in water.

Of drugs

The drugs-gemostaticescoe. Neutralizes the heparin has gemostaticski and weak antikoagulyaim properties. Treated with geparinom stable complexes, and the ability to disappear unchanged hinder blood coagulation. Complexation to cationic lots groups (through arginina), which is associated with the anionic centres unchanged. Effective in certain types gemorragi of geparinopodobnami human blood clotting. The effect is instantaneous (to cope), and continues at 2

Indications

Bleeding from overdose unchanged, in the operation against the backdrop geparinova therapy after operations on the heart and blood vessels with ekstrakorporalnam blood.

Contraindications

Hypersensitivity, and idiopathic congenital gipergeparinemia expressed gipotenzia, anaemia, lack napochechnikov crust.

Side-Effects

Aetiology, hypertension / gipotenzia, feeling heat, causing allergic reactions.

Patient interaction

Is not compatible with the liquid and penitsillinami.

Overdosing

It may be accompanied by bleeding, as protamine has antikoagulyatini own activity.

Precautions

During the therapy needed to be monitored in blood coagulability. Before the introduction to verify the adequacy of the patient's blood (gipovolemia increases the risk of collapse).

Dosing and Administration

In / in, or struino drip. At 5 ml, if necessary, repeated at 15 min, the maximum dose to 150 mg / h (1 mg Protamine neutralizes 1 mg unchanged). The artistic methods-drip 2 reception at intervals of 6900, the daily dose 5-8 mg / kg body weight, the maximum rate is three days.

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