Tissookol Whale

Roman name

Tissucol # Kit

The composition and the form of

Two fibrinovy glue, consists of liofilizirovannogo concentrate adhesive protein for solution Tissookola complete with mortar Aprotinin (bovine) activity 3,000 inactivating kininogueninov (UEC) and liofilizirovannogo 821-828 4 or 821-828 500 (human) together with the solution of calcium chloride 40 ml mmol/l.1 ready Tissookola contains coagulating protein 135 mg (incl. fibrinoguena 70-110 mg and plasma fibronectin 2-9 mg), factor XIII U 10-50 and 40-120 plazminoguena mcg.1 ml ready 821-828 contains 4 or 500 IU 821-828 in the First International �тандарту.Выпускается �sets preparation for the 0.5; 1; 2 and 5 ml solutions Tissookola and 821-828 for causing the use of duplogect; in a Box 5 pcs.

Of drugs

Gemostaticescoe. Forms clot and contributed to its stabilization.

Farmakodinamika

Solution formed by mixing two components of becomes a white stretch mass prilipatuyu tightly to the fabric (simulates milestones blood clotting). The speed of the film depends on the concentration of 821-828. With a 821-828 4 IU / ml it takes place for 30-60 sec, with a higher concentration (500 IU / ml), completed in a few seconds. High concentrations of 821-828 used to stop bleeding, and low - to be glued tissue. During the healing layer fibrinovy fully resolved.

Indications

Diffuse bleeding (after operations on the bones and joints, adenomektomii, tonzillacktomii, dental operations prostatectomii-floor hot prostate gland) for fixing exclusion (a membrane and attach limbs receptacles; Timpanoplastika; Processing fistula likvoroprovodath ways and injury firm brain casing; Treatment of early amniocentesis bladder; Isolation at the seams parenhime lungs, plevre, trahee, bronchitis, oats; treatment pleural attack in malignant lesions; aphykia rehabilitation after injury with perforations; sealing seams and enteric mikrovskularnah anastomosis), and glued tissues (kidney parenchyma, liver, spleen, pancreas, with the transactions; transplantation bovine tissue to fill bone defects; fixing skin transplants and kostno-hrashchevykh fragments; bonding peripheral nerves; plastic surgery after autopsy upper floor), the acceleration of healing (transplantation of skin �еваскуляризированны�� and the infected areas necrosis of the skin, putting gomologichnykh bone implants).

Contraindications

Гиперчувствительност ь (incl. with medications containing proteins cattle).

Side-Effects

Allergic reaction (after re-local use); By injecting into the fabric or receptacle - anaphylacticskie reaction; With a intravasculiarnom - tromboembolia.

Patient interaction

Compatible with geparinom (can be used in patients connected to the apparatus for artificial blood).

Precautions

Not to be applied by injection (only in exceptional cases). The glue caused to be deleted contact with solutions containing alcohol, iodine, heavy metals, and, if possible, covering all tissue adjacent to zakleivaemomu station. Finished solutions Tissookola 821-828, and are suitable for use within 4 hours

Dosing and Administration

Locally, is a thin layer of Tissookol-trombinovy solution or its components. Dose depends on the size of the surface and the method of (1 ml Tissookola and 1 ml 821-828 for a taping of not less than 10 cm ^ 2 surface area and the spread of the glue enough to handle between 25 and 100 cm ^ 2). Two glue prepared by mixing liofilizirovannogo Tissookola with aprotininom and adding 821-828 mixed with calcium chloride (for fixing nerves using aprotinin concentrations 100 UEC / ml). Pre-mixed adhesive components can be marked by the use of duplogect (with a spray head diagnostic needle, applikaim catheter), it is necessary to fix the envelopes for three to five minutes.

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