Epoetin alfa

Chemical name

альфа-(1-165)-Эритропоэт��н (gennoingenernyi); glikoprotein consisting of 165 amino acids

Of drugs

The drugs-protivoanemicescoe, eritropoeticescoe. Promoting mitosis and differentiation eritroidnykh клеток-предшественни��ов. Increase the number of red cells, reticulocytes, hemoglobin content, improves the heart and blood тканей.Биодоступност�� after s / by the introduction of 25%, C_max achieved in 12 to 18 hours; T_1/2 to 24 h after s / to the introduction; in the on / in a T_1/2 is 5-6 h, with periodic injections in the blood koumouliruet not.

Indications

Anaemia : with chronic renal failure, gemodialise, Vic-infectiah against the backdrop of AZT treatment, zitostaticescoy chemotherapy, the premature newborns; Training patients with anaemia to deal with the expected massive krovopoterei.

Contraindications

Hypersensitivity, uncontrolled arterial hypertension, blindness status, pregnancy, breast-feeding (at the end of treatment).

Side-Effects

Hyperten, headache, a feeling of tiredness, fatigue, dizziness, arthralgia, zagrudinne pain, nausea, vomiting, diarrhea, swelling, trombofilia, convulsions, skin reaction at the site of injection.

Overdosing

Symptoms : policitemia and changing gematokrita. Special treatment is required on a temporary repeal epoetin (before normalization gematokrita).

Precautions

It should not be used in combination with other solutions drugs. There is a need to regularly monitor gematokrit for the reduced efficiency and the development of resistance. We recommend using plastic syringes and tanks, and avoid glass.

Dosing and Administration

P / to, or / 3 times a week, 50 U / kg to an increase of up to 75 U / kg after one month; If necessary (resistance) dose increase of 25 U / kg every month, but not more than 200 U / kg Contributing dose picked individually, taking into account gematokrita (no more than about 35. %); After dialysis for 30-100 U / kg three times a week.

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