Epoetin beta

Chemical name

бета-(1-165)-Эритропоэти�� (gennoingenernyi); glikoprotein consisting of 165 amino acids

Of drugs

The drugs-gemopoeticescoe, eritropoeticescoe. Increase the number of red cells and reticulocytes, hemoglobin content, activates the synthesis of tension. Normalizes reduced gematokrit : its increased begins in four weeks regular лечения.Биодоступнос��ь the p / to the introduction-23-42% dose-T_1/2 12-28 h after the / in a 12-hour

Indications

Dysautonomia different genesis (chronic renal failure, prematurity births chemotherapy neoplasms), the increase in blood for autotransfuzii.

Contraindications

Hypersensitivity, refrakternaya arterial hypertension, unstable stenocardia, that the history myocardial infarction, stroke or embolism, pregnancy, breast-feeding.

Side-Effects

Grippopodobnaya symptoms (early treatment), the AD hypertonic kriz events encephalopathy (headaches, sputannosti consciousness, сенсорно-двигательны�� violation); increasing the concentration of potassium and phosphate in the cell, B19, trombozitos, allergic reaction (rash, urticaria), the reaction at the injection.

Specific guidance

The caution should be appointed with hypertension, nefroskleroze, chronic renal failure, epilepsy, trombozitoze, malignant tumors, sickle-cell anemia and vascular diseases. A weekly monitoring liver function, metabolism, AD blood (especially platelets, gematokrit, ferritin).

Overdosing

Symptoms : hypertension, Eritrotsitoz.lechenie : prevention of excessive hydration, venesekcia, cigarette therapy (in the face of the epoetina).

Dosing and Administration

In / in, c / GMT In chronic renal failure and 20 IU / kg three times a week, or 10 IU / kg, 7 days a week. If the increase gematokrita Increasing dose of 20 IU per month; In / in-40 IU / kg three times a week with an increase of 40 IU every 4 weeks with inefficiency. Supporting dose-30 IU / kg three times a week; Premature babies-250 IU / kg three times a week, treat the sick-o / to 450 IU / kg / week for 3-7 receptions. The maximum dose to 720 IU / kg

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