Epomaks

Roman name

Epomax #

The composition and the form of

1 orange 1 ml solution for injection contains omega epoetina 2000 or 4000 IU. Other ingredients : sodium chloride 8.18 mg, odnoosnovny sodium phosphate 1.56 mg, sodium hydroxide for pH at a 7.2, RNA human albumin 1.0 mg, water for injection; In a box six bottles.

Characteristics

Rekombinantny human erythropoietin - glikopeptid received genno-ingenerian method (recombinant DNA).

Of drugs

Eritropoeticescoe.

Indications

Anaemia in the face of chronic kidney failure.

Pregnancy and lactation

Is not recommended, although it is permissible in Groups II and III trimestrah on strict conditions and the lowest dose. Nursing mothers for a period of treatment should abandon breastfeeding.

Contraindications

Гиперчувствительност ь (incl. for human albumin savoroternmu or derivative products from mammals), uncontrolled arterial hypertension.

Side-Effects

Arterial hypertension, brain, giperkaliemia, grippopodobnyy syndrome (headache, chills, mialgii). In some cases, anaphylactic shock and other adverse reactions : swelling, fatigue, convulsions gastrocnemius muscles tachycardia, gipotenzia, stenocardia, bronchitis, diarrhoea, skin itch.

Overdosing

There gematokrita increase, the level of hemoglobin, the blood viscosity, hypertension Trombozom.lechenie : lifting drug, cigarette and / or antikoagulyantnaya therapy.

Precautions

In the case of development (at the time of treatment) giperwolemicescoy gipotenzivnuu hypertension therapy should be cautious because possibly significant increase in the viscosity of blood. If it is not impact on the AD product should be lifted. A test haemoglobin and gematokrit before reaching values 100-120 g / m for hemoglobin and 30-35 vol% for gematokrita-out at least two times a week and then once a week. As for the treatment of anemia improved appetite increases potassium uptake and protein shows Diet and dialysis before reaching normal values whey potassium, creatinine, etc. In therapy patients with thrombosis (incl. history) once a month tests for coagulation (if necessary appointed antikoagulyantnaya therapy). Be wary appoint patients with arterial hypertension, coronary artery disease (coincidentally or antigipertenzivnuu antikoagulyantnuu therapy). Control contingency iron before and during treatment weekly-level ferritina must be above 100 ng / J Before treatment should be deleted factors weakening effects : vitamin B_12, folic acid, aluminum poisoning, infections, therapy or korticosteroidami immunodepressantami.

Dosing and Administration

P / to the in / in the initial dose-20-50 IU / kg body weight three times a week, with a gradual increase in dose or frequency of up to impact. When the levels of hemoglobin (120 g / cm) and gematokrita (35 vol%) no treatment or dose reduction. If there are therapeutic response in the initial phase appointed within two weeks three times a week until the values 40-55 IU / kg (no more than 120-165 IU / kg per week). The dosage may be increased to 60-75 IU / kg (no more than 180-225 IU / kg per week). The course continues until the normal levels of hemoglobin, 100-120 g / m and gematokrita 30-35 vol%. Total weekly dose should not exceed 225 IU / kg The level of hemoglobin and gematokrit normalized within 3-4 weeks. Supporting dose (for the preservation of the ± 10%), 60-100 IU / kg per week for 2-3 reception. Maximum supporting dose is 200 IU / kg three times a week (600 IU / kg per week). At lower values gematokrita hemoglobin and 10% below the need to increase dose. Dosage chosen individually : at the beginning of each two-week period, dose can be increased by 15 to 20 IU / kg (total dose week increased by 30 to 60 IU / kg). Dosage preparation, in which the haemoglobin levels and gematokrit returned to the range is used for further treatment before the next increase in the range of 10% or of side effects. When replacing recombinant eritropoetinov Epomaksom dose should not be higher dose Recombinant Erythropoietin (50-75 IU / kg weekly divided by the reception 2-3). The projected decrease haemoglobin levels after the treatment, 5 g / m per week.

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