Filgrastim

Chemical name

N-L-Метионилколониести мулирующий factor (human gennoingenernyi); neglikozilirovanny protein consisting of 175 amino acids

Characteristics

The antiseptic colourless liquid for injecting.

Of drugs

The drugs-leikopoeticescoe. Does granoulozitopoez. Interacts with receptors on the surface of cells haemogenic, accelerates biosynthesis and the release of Klebsiella in bone Mozge.objem of 150 ml / kg T_1/2-3.5 h, Cl - 0.6 ml / min / kg

Indications

Neutropenia (disease, recurrent, malignant), in combination with severe infections in history, and neutropenia febrilnaya neutropenia in chemotherapy zitotoksicski nemieloidnykh malignant diseases or mieloablativna therapy followed transplants bone marrow, the mobilization autologichnykh клеток-предшественни��ов gemopoaiza in peripheral blood after mielosupressivna therapy.

Contraindications

Hypersensitivity, severe congenital neutropenia with abnormal cytogenetics (Kostmana syndrome).

Side-Effects

Kostno-myshechne pain gipotenzia, dizuria, gematuria, proteinurija, allergic reactions (usually in the / in infusions in the injection site), vasculit, spleno- and gepatomegalia, headache, diarrhea, anemia, thrombocytopenia, active bleeding, increased liver transaminaz blood uratemia, alopecia, osteoporosis, hypoglycaemia.

Patient interaction

Ftorurazil can provoke acute neutropenia.

Dosing and Administration

P / or to the on / in (cefuroxim). Treatment through the beginning (at the earliest) 24 h after chemotherapy. Zitotoksicski induced neutropenia - 0500000 U / kg per day; Mieloablatius therapy with transplant bone marrow-1000000 U / kg per day; Mobilization клеток-предшественни��ов gemopoaiza - 1000000 U / kg / day for 6 days; severe chronic disease and neutropenia-initial dose 1.2 million U / kg per day; malignant or periodic neutropenia-initial dose 0.5 million U / kg per day. Treatment continued until the restoration of normalcy in Klebsiella (usually about two weeks).

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