Lenograstim

Chemical name

Genno-ingenernyi glikoprotein consisting of 174 amino acid residues (glycolic human granulocyte colony factor)

Of drugs

The drugs-leikopoeticescoe. Do active bone marrow, it accelerates education, and access mature Klebsiella by increasing their numbers in the peripheral blood. The reducyruet risk of infectious complications. Stimulating effect on gemopoaiza, accelerated aging cells and improve their infection control functions can significantly reduce the toxicity and improve the portability of high - химиотерапии.Биодост��пность the p / for the introduction of 30%. The volume of 1 l / kg T_1/2, 3-4 p.m. Inside the hydrolyses to oligopeptidov in urine unchanged to see only about 1% Dozy.intencivny exit cells in peripheral blood starts very quickly (by the end of the first day). Reliably reduces the number of patients with deep neitropenia the infection twice reduces the need for re-symmetry and the need for antimicrobial therapy. It is a significant increase intensity anticancer chemotherapy. The likelihood neitropenicescoy fever reduced 5 times. In appointing patients with idiopathic, cyclical and congenital neitropenia raises the Klebsiella from an average of 500 to 1500/mkl with 5-kratnam reduction in the length of infectious episodes and 3-kratnam lower frequency mukozita. Decreases of postoperative infectious complications and postoperative mortality in cancer operations (resection and plastic oesophagus, etc.). Increases fungicidal activity Klebsiella that, in some cases, exclude protivogribkovu therapy. Effective in combination with nutritional therapy in the treatment of deep mycosis. Increases survival of patients with recurrent malignant lymphoma and отечно-инфильтративн��й forms of breast cancer. In patients with severe pneumonia, in the normal course of Klebsiella reduces rate, the frequency of complications (respiratory distress-sindroma, disseminirovannogo vnutrisosudistogo blood clotting, empiema pleura), accelerates radiology positive momentum.

Indications

Neutropenia : after chemotherapy (primary and secondary prevention), idiopathic, congenital, cyclic, the AIDS; Neitropenica infection intensification chemotherapy, a blood stem cells for subsequent protection gemopoaiza, prevention of infection after surgical interventions, severe infection in oncological patients (in combination with antibiotics).

Contraindications

Hypersensitivity, mieloproliferativee disease, severe violations of the liver and kidney failure, pregnancy, breast-feeding (at the end of treatment).

Side-Effects

Mialgia, ossalgia, increased body temperature, leucocytosis, anaemia, pain in the injection.

Precautions

The total duration of treatment in a day should not exceed four weeks. Showed regular monitoring of blood, and platelets in the peripheral blood. If expressed leikozitoza (> 50h10 ^ 9 / l) a break. When pain in the bones or fever designate NPVS. Against the backdrop of anticancer chemotherapy introduction lenograstima begin in 24-48 hours after the end of chemotherapy and thus in the last days before the start of the next course.

Dosing and Administration

P / to the in / in, in the dose of 19.2 million IU / m ^ 2, once a day. The contents of sealed dissolved in water for injection immediately before use; For a / in the solution obtained diluted 100 ml physiological solution. Normal Course duration-3-7 days (up to 28 days) to achieve and maintain the number of cells at the level of 10000/mkl within 3 days. To mobilize клеток-предшественни��ов gemopoaiza in daily chemotherapy introduction beginning in 24-48 hours after the last �имиотерапевтическог�� agent. When treating severe infections in patients with a normal number of white adults, in the dose of 33.6 million IU / day in combination with antibiotics or fungicide products. To prevent infectious complications of cosmetic surgery for gastric : in the two days before the operation and for a period of 7 days thereafter.

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