Molgramostim

Chemical name

Highly water-soluble peptides consisting of 127 amino acid residues; Rekombinantny human гранулоцитарно-макро��агальный colony factor

Of drugs

The drugs-leikopoeticescoe. Does proliferatiou and differentiation predecessors, the contents of mature cells in the peripheral blood increased granulozitov, monocytes and macrophages. Increases functional activity of mature Klebsiella - intensifies phagocytosis increases extent "Respiratory bang (for education to 90% of active forms of oxygen and is one of the most important mechanisms of phagocytosis), enhances cytotoxicity against malignant cells. And immunotropona activity accelerates cell maturation. Is enhance antigen expression of class II HLA at monocitah and increase production of Antitel.vrema C_max is about 3 hours T_1/2 ranges from 1 to 3 hours, depending on the method of introduction. Therapeutic effect occurs 2-4 days after injection. In mielodisplasticeskih syndromes effectively normalizes mielopoez. Decreases recovery time mieloidnyi blood after bone-marrow transplants in patients with acute leukaemia, is not affecting and being affected by the overall survival and time to development of recidivism. Alleviate lakopeniu after chemotherapy and reliably printers profound neutropenia and infectious complications, reduces the need for antibiotikoterapii and provides the possibility of chemotherapy. Increases bezretidivnuu survival of patients with resistant lymphomas.

Indications

Lakopenia in pathological conditions involving violation mieloidnyi blood (including AIDS and other infectious diseases, mielodisplasticescom syndrome), or against the backdrop of anticancer chemotherapy, the primary prevention of neutropenia and neitropenicescoy infection with a high risk of its development after chemotherapy (eg, guidelines on the development of febrilna neutropenia in the first course of chemotherapy); to reduce mielotoksicski of antivirals for the treatment of Cytomegalovirus infections in AIDS patients, restoring blood mieloidnyi in bone-marrow transplants; Stimulation release cells, gemopoaiza predecessors of the bone marrow in the peripheral blood for subsequent allocation method leikafereza and transplantation (preparation for anticancer chemotherapy super doses).

Contraindications

Hypersensitivity, mieloidnye leukaemia, lung diseases, auto-immune diseases, pregnancy, breast-feeding (at the end of treatment).

Side-Effects

The fever, anorexia, diarrhoea phenomenon pains in the abdomen, disease, shortness of breath, weakness, sweating, ossalgia, mialgia, pain in the chest domain, sudorozhny syndrome, headaches, dizziness, fainting, pareza, raising vnutricerepnogo pressure of cerebral circulation and hypotension, Already, the acute cardiac insufficiency, ekssoudativei pleurisy, pericardit, thrombocytopenia, eozinofilia, reducing albuminates and hemoglobin in the blood, allergic (skin rashes, swelling angioneuroticeski, bronhospazm, anaphylactic shock) and the local reaction.

Overdosing

Symptoms (with the chronic form) : tachycardia, hypotension, fever, weakness, headaches, Mialgia.lechenie : symptomatic.

Precautions

Treatment should be carried out only in a specialized institution (Cancer, gematologicaki etc.). The first time a drug should take into account the possibility of life allergic reactions. Constant monitoring of peripheral blood (leikozita, platelets, leikocitarnaya formula haemoglobin gematokrit level Zdrowia), and lung diseases, dynamic measuring gas exchange and pulmonary ventilation. Identifying serosita (pleurisy, pericardit) requires immediate repeal.

Dosing and Administration

P / to the in / 386/1989 Solution are ex tempore, dissolving the contents sealed in water for injection. The normal dose-5-10 µ g / kg / day, with neitropeniceskih infections, 1-5 µ g / kg / day, mielodisplasticescom syndrome - 3 µ g / kg / sut. For the application in the anticancer chemotherapy first is the introduction of no earlier than a day after the application химиотерапевтическог о 's recommended rate is 7-10 days. Introduction to transplant bone marrow beginning on the day after the operation, the duration and dose picked on the basis of the number of cells (reference value 1h10 ^ 4 / mm ^ 3).

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