Neipogen

Roman name

Neupogen

The composition and the form of

1 orange 1 and 1.6 ml solution for injection contains filgrastima 30 and 48 million IU respectively; in a Box 5 flakonov.1 spric-tubik from 0.5 ml solution for injection, 30 or 48 million IU; complete with needle, in one box set.

Characteristics

Neglikolizirovanny rekombinantny granulocyte colony factor rights. Highly protein consisting of 175 amino acids, which are used genetically engineered strain of the E.coli bacteria.

Farmakodinamika

It is a marked increase in the number of Klebsiella in the peripheral blood, with a small increase in the number of monocytes. The increase in the number of Klebsiella depends on the size of dose. Activates клетки-предшественни��ы in the peripheral blood (the patient �летки-предшественниц ы gemopoaiza of peripheral blood can be taken from a patient and introduce a therapy after high-dose cytotoxic funds as a substitute for bone-marrow transplants, or in addition to it).

Indications

Neutropenia (including in patients receiving cytotoxic to the malignant diseases, but chronic and mielolakoza миелодиспластическог о syndrome); to reduce the length of neutropenia and its clinical effects in patients with pre-transplant bone marrow; to activate autologichnykh �леток-предшественник ов in the peripheral blood; mielosupressus chemotherapy (with a view to accelerating the reconstruction of blood after being kletki-predshestvennica); heavy inheritance, or recurrent malignant neutropenia (number Klebsiella less than or equal to 500 1 l), with a heavy or emergent infections in history.

Contraindications

Hypersensitivity, heavy inheritance neutropenia (Kostmann syndrome) with a pathological zitogenetika, pregnancy, breast-feeding (suspended).

Side-Effects

Myshern-kostnye pain, urination disorders, a decline AD increase in liver transaminaz and alkaline phosphatase.

Overdosing

Effects overdose Neipogena Neizwestna.cerez 1-2 days after the preparation of Klebsiella circulating normally reduced by 50% with a return to normal values in 1-7 days.

Precautions

There is a need for regular monitoring of blood (to avoid leikozitoza), and platelets.

Dosing and Administration

P / to and / with a monthly rate of 0.5 million U (5 µ g) / kg once a day. Patients preparing for bone-marrow transplants, the recommended initial dose of 10 µ g / kg / day (in / for a period of 0,5-24 p, p / k). The preparation raise in 20 ml of 5% glucose solution. The interval between the introduction Neipogena and cytostatica should not be less than 24 hours To activate клеток-предшественни��ов gemopoaiza from peripheral blood as a stand-alone therapy appoint 10 µ g / kg / day, by continuing round-the-clock in / in real time or s / c injection for 6 days; mielosupressivna after chemotherapy, c / to 5 µ g / kg / day, starting with the first days after the end of chemotherapy before reaching normal values Klebsiella. Patients with severe chronic neitropenia-initial dose in hereditary neutropenia 12 µ g / kg / day p / c with malignant or recurring - 5 µ g / kg / day p / model Daily dose of introducing one or more receptions.

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