Polidan

Roman name

Polydanum

The composition and the form of

1 bottle with 5 ml solution for injection contains nukleospermata sodium 75 mg; in a cardboard unit 1 and 5 bottles.

Characteristics

Vsokoochischennaya standardized mixture of sodium salts polihlorgidratov derivatives DNA and RNA obtained from molok sturgeon.

Of drugs

Gemopoeticescoe, leikopoeticescoe. Is driving blood indirect action. It has the ability to stimulate haematopoiesis and increases production of endogenous koloniestimuliruth factors acting through the estate, inducing blood. Is raising platelets. Impact of immunosupression after PCTs and LT, increasing the CD4 + increases their share of the balance immunoregulyathornah Inc. (CD4 + / CD8 +), while high proliferativuyu activity logs. Significantly reduces superoxidedismutase and malonovogo dialdegida with moderate antiauxidantnuu activity.

Pharmacokinetics

Rapidly absorbed in the blood system from the point of injection. C_max plasma in the / m is a 60 min. The concentration of the drug in the marrow maintained for a period of 72 hours This clearly supports the colony effect that is much longer than the original level. Thus, the re-injection worth no earlier than 72 hours Most troponosti resistance to the bone marrow, limfouzla, spleen, thymus, kidney. Penetrates the GEB. T_1/2 - 69-72 hours Write, unedited, and in the form of metabolites mainly with urine and partly with faeces.

Clinical pharmacology

Decreases gematotoksicnosti caused by the high doses of drugs, restores levels лейкоцитов/нейтрофил��в in the peripheral blood. Warn development leiko- and neutropenia and related infectious complications (bacterial, fungal, viral).

Indications

Lakopenia caused by radiation and zitostaticescoy therapy (treatment and prevention).

Contraindications

Hypersensitivity, pregnancy, breast-feeding, child up to three years.

Side-Effects

Concentrations increase body temperature (up to 38 ° C), hyperemia and soreness at the injection, which do not require special treatment.

Dosing and Administration

P / or to the / m (slow during 1.5-2 min), tentatively sogrev bottle in his hand and body temperature. To reduce the impact of pain may be in the / m, with the addition of 0.5 ml лидокаина.Рекомендуе��ая single dose for adults and children over three years of age, from 42 mg / m ^ 2 per day, but not less than 66 mg / day (regardless of the surface area of the body and the age of the patient); maximum single dose-150 Mg.prophylactika leiko / neutropenia : a good scheme, ranging from 66 to 150 mg once 24 hours before the start of chemotherapy. Allowed introduction of 66 to 150 mg once within 24 hours after completion of the course Himioterapii.lechenie leiko / neutropenia : single dose (from 66 to 150 mg) 1-5 injections at intervals of 3-7 days.

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