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RecormonSee also Epoetin betaRoman nameRecormonThe composition and the form ofone bottle contains recombinant human Erythropoietin as a liofilizirovannogo substances for 1000, 2000 or 5000 IU; together with the solvent in the USD 1 ml (10 pcs.) , in a cardboard box 10 flakonov.1 cartridge spric-rucki "Reko-pen" - 10,000 or 20,000 IU; together with the solvent, in a carton 1 pc.PharmacokineticsBioavailability when s / to the introduction of 23-42%. T_1/2 when s / to the introduction-13-28 hrs, as in / in-4-12 pmClinical pharmacologyEffect (the gematokrita) is a four weeks after the start of treatment.IndicationsAnaemia kidney genesis in patients with chronic renal insufficiency, anemia in patients with malignant neoplasms, increasing blood, prevention of anaemia among premature newborns.Pregnancy and lactationPerhaps only on strict conditions.ContraindicationsHypersensitivity, severe arterial hypertension. When using to increase blood can assign patients in the previous month suffered myocardial infarction or stroke; Patients suffering from unstable and stroke patients at risk for DVT deep vein.Side-EffectsIncreased blood pressure or strengthening existing hypertension, hypertonic kriz events encephalopathy; Rarely trombozitos, pulmonary shunts, skin rashes, urticaria, the reactions at the injection; In some cases, tranzithornoe increasing concentrations of potassium and phosphate in the cell.Patient interactionIf you are applying gipotenziveh funds may need individual dose selection. When using drugs affecting blood (such as iron), can increase the catalytic effect on eritropoez.OverdosingIn overdose can develop hypertension and eritrotsitoz. In the case of hypertension should be deleted excess hydratation. If eritrotsitoza and gipergidratace depend on the development of excess fluid.PrecautionsIt can be used only in the hospital, the first dose should be supervised by a doctor, and then monitored the patient. Gently appoint patients with arterial hypertension nefrosklerozom, malignant tumours, epilepsy, chronic renal insufficiency, trombozitozom, sickle cell disease and vascular diseases. A weekly monitoring blood pressure and counting uniform of the blood (especially platelets), the control gematokrita level ferritina in whey, monitoring liver function and metabolism.Dosing and AdministrationIn / in, c / GMT When treating anemia in patients with chronic renal insufficiency in the p / to a starting dose of 20 IU / kg three times a week, or 10 IU / kg, 7 days a week; In the case of the weak gematokrita dose increased by 20 IU / kg three times a week every month. The on / in the introduction initial dosage is 40 IU / kg three times a week; Insufficient Effect dose increased by 40 IU / kg every 4 weeks. In any of the maximum dose should not exceed 720 IU / kg Average supporting dose is about 30 IU / kg three times a week. To prevent anaemia in premature newborns product is s / to the dose of 250 IU / kg three times a week. For the prevention and treatment of anemia in cancer patients being mean s / to the dose of 450 IU / kg / week, sharing the weekly intake of 3 or 7 varieties.Storage conditionsThe temperature 2-8 ° CShelf life2The registration014262/01 |
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