Directory → Gematotropona funds → Amphetamine gemopoaiza → Vero-epoetin
This page is translated automatically with a help of Google Translate

Vero-epoetin

See also Epoetin beta

Roman name

Vero-Epoetin

Pharmacokinetics

When s / to the introduction C_max achieved through 12-28 hrs, and on / in the introduction, through 15 min. Bioavailability when s / by the introduction of 46% of the bioavailability of / in the introduction. T_1/2 when s / to the introduction-p 13-28, in the / in a 12-hour

Farmakodinamika

Is glikoproteinom - mutzostimulirutm factor and hormone differentiation contributing to the formation of red stem cells. Increase the number of red cells, reticulocytes, gematokrit and Palestinians (haemoglobin) in the blood, as well as the speed of iron in the cells.

Clinical pharmacology

In chronic leikocitarnom leikoze response to therapy epoetinom beta occurs in the two weeks later than in patients with mielomna disease started chemotherapy and solid tumors.

Indications

Prophylaxis and treatment of anaemia different genesis : anaemia in HEN (chronic kidney failure), including : in patients in gemodialise; anaemia in patients with solid tumours receiving chemotherapy drugs platinum (cisplatin 75 mg / m ^ 2 in the cycle, carboplatin 350 mg / m ^ | 2 |); anemia in adult patients with mielomna disease and started chemotherapy low zlokacestvennosti and chronic leukaemia limfocitarian receiving protivoopujolevu therapy, and the relative lack of endogenous Erythropoietin (defined as disproportionately low, the degree of anaemia, Erythropoietin concentration in the serum) .- The increase in blood for the follow-autoguemotransfuzii Prevention of anaemia among premature babies born weighing 0,75-1,5 kg up to 34 weeks of pregnancy.

Contraindications

Гиперчувствительност ь (with the spric-rucki Reko-pen, including the benzoic acid-metabolitu benzyl alcohol), severe arterial hypertension. When using with a view to increasing blood for autoguemotransfuzii (optional) : carry myocardial infarction or stroke with a time less than one month, stenocardia fragile, the risk of thrombosis deep vein and Tromboamboliy.s caution : pregnancy, breastfeeding, refrakternaya anaemia in the бласттрансформирован ных cells trombozitos, epilepsy, liver failure, expressed moderate anaemia (Palestinians 100-130 g / l or gematokrit 30-39%, with no deficit Fe), the body weight of less than 50 kg (to increase blood for follow autoguemotransfuzii).

Specific guidance

Patients with severe forms of phenylketonuria should be borne in mind that certain dosage forms, as a subsidiary substances contain fenilalanin.

Patient interaction

Is not compatible with other LAN in a single sprite.

Precautions

Inadequate preparation of healthy people (such as drugs) can lead to a sharp increase in gematokrita, with life-threatening complications from cardiovascular Sistema.iz-za possible development anaphylactoidnykh reactions first dose of the drug should be controlled Vracha.sleduet monitor periodically gematokrit before reaching the 30-35% (Palestinians 100-120 g / l). In the future, they want to define the Egenedelno.iz-za gematokrita often required to increase dose heparin during hemodialysis. With inadequate geparinizitia possible Haaretz dializna system shunts labor, especially in patients with a tendency towards hypotension or complications arteriovenozna Fistula (stenoses, anevrizma etc.). Such patients are encouraged to audit early shunt and timely prevention trombozov (eg AC). Prior to the treatment epoetinom beta should be deleted deficit zianokobalamina and folic acid because they reduce the effectiveness Preparata.rezkoe increase in the concentration of Al ^ | 3 + | resulting from the treatment of kidney failure may undercut the effectiveness epoetina Beta.reshenie on drugs in patients with nefrosklerozom not on dialysis must be taken individually, as Such patients it is a more rapid deterioration in the Pocek.v course of treatment is recommended to periodically monitor the concentration of potassium and phosphate in the blood serum. If giperkaliemii to temporarily lift product to the normalization of Kalia.rekomenduetsa monitor AD incl. between dialysis sessions, with the rapid increase gematokrita, and the cancer patients, especially at the beginning of treatment. The AD can be kupirovano PP, in the absence of the effect a temporary break in treatment epoetinom beta. In developing gipertoniceski kriza hold urgent Meropriatia.u cancer patients, the sick, preparing for the follow-autotransfuzii and receiving epoetin beta, the higher the frequency of thromboembolitic complications, although a clear causal link to the reception withdrawal Ustanovlena.v first 8 weeks of therapy required weekly uniform counting of the blood (especially platelets). The increase in the number of platelets more than 150,000 / µ l of the reference values should be treated Prerwati.esli epoetin beta appoint the fence autologicna blood, should follow the recommendations of the donation : blood can be taken only in patients with gematokritom 33% or more (or the Palestinians is not less than 110 g / l). Special caution should be exercised in patients weighing less than 50 kg. The blood zabiraemy instantly shall not exceed 12% of the estimated blood volume Patienta.v most cases at the same time as the increase gematokrita declining ferritina concentration in the serum. All patients with renal anemia genesis, and the concentration of serum ferritina less than 100 µ g / l or transferrine saturation less than 20% to oral iron in the dose of 200-300 mg / sut. Patients with cancer and haematological diseases therapy drugs iron hold on the same principles; And patients with mielomna disease started chemotherapy or chronic leukaemia limfocitarian with transferrine saturation less than 25% can be administered 100 mg of iron per week / 386/1989 Premature children oral therapy drugs iron dose of 2 mg / day to be appointed as soon as possible (at the latest 14 days of life). Dose iron corrigiruut depending on the concentration of whey ferritina. If it is firm below 100 µ g / ml, or there are other signs of deficiency of iron, dose iron supplements should be increased to 10 mg / day, and the therapy to signs of edema deficit Jeleza.u patients prepared to give blood for autoguemotransfuzii follow, as well as in the temporary iron deficiency, oral therapy drugs iron dose of 300 mg / day should start at the same time ...

Storage conditions

In dry, the dark place at a temperature of 2-8 ° C

Shelf life

2

The registration

(OL)

The drug forms

Porous amorphous mass of white, or almost white.

All products of this group