Perftoran

Roman name

Perftoranum

The composition and the form of

Submikronnaya (0.05-0.15 μm) 10% emulsion (white with a blue golubovatam) on the basis of PFOS - 19.5 g; Proksanola - 268-4 g sodium chloride 0.6 g, potassium chloride, 0.039 g magnesium chloride, 0.019 g sodium gidrocarbonata - 0.065 g sodium hydrogen-0.02 g glucose, 0.2 g; Bottled 50, 100, 200 and 400 ml.

Of drugs

Gas, plazmozameshchatee, desintoksikatine, membranes, cardioproteguoe, dioreticescoe, protivosokowoe. Does calzieve channels. Is reversible (similar to haemoglobin) bind and transport oxygen, carbon dioxide.

Pharmacokinetics

Do not metabolised in the body (chemically inert). Deposited in the ретикулоэндотелиальн ой the temporarily stored in the liver, spleen, bone marrow. Completely out of the body within a period of 18 to 24 months through the lungs and skin.

Clinical pharmacology

Transportation function perftorana linked to the ability to transfer oxygen (7 on. % With a partial Go_2 pressure of 760 mm Hg), and carbon dioxide (60 vol. % At pCO_2-760 mm Hg), as well as with high surface gas behind the significant increase in the rate of diffusion of oxygen. Submikronny particle size emulsion allows sufficient oxygen supply ishemizirovanne stations tissue hemodinami ffa cs rebuilding. Proksanol - stabilizer, which is part of the flow, improves the flow properties of blood and peripheral microcirculation by reducing viscosity and aggregation of cells.

Indications

Gipovolemia and hypoxia due krovopoteri, shock, injuries, poisoning; Violations circulation, woven metabolism gas; Protivojishemical protection donor organs; Use devices artificial blood circulation.

Pregnancy and lactation

Only for health reasons.

Contraindications

Hypersensitivity, hemophilia, allergic disease.

Side-Effects

Sometimes there hyperemia, hyperthermia, tachycardia, hypotension, headache, pain in the sternum and lumbar area, difficulty breathing, allergic (incl. anaphylactoidnye) reactions.

Patient interaction

Incompatible with poliglukine, reopoliglukine, auxiatilkrahmalom (if necessary recent being before or after infusions perftorana); Compatible with the blood, albumin solution, glucose, antibiotics, and izotoniceski christalloidnam solutions.

Precautions

There should be imposed on the same system and use the same apparatus artificial circulatory Solutions dekstranov. Not suitable to the application, if after thawing with shaking at the bottom bottle is empty.

Dosing and Administration

In / in drip or struino, after the first 3-5 and the next 30 drops should be suspended for 3 minutes (for the evaluation of the results of a biological sample). Doses, and the interval between the introduction of choice, in accordance with the indications and the patient. The normal dose-5-30 ml / kg body weight; Possibly re-introduction to the same dose three times at intervals of 1-4 days. Maximum dose : single-30 ml / kg daily-100 ml / kg If necessary to improve oksigenatingo effect that the supply air is enriched with oxygen (60%).

Storage conditions

emuls.d / inf. : List B. The frozen-at temperatures from -4 to -18 ° C. In razmorojennom form, at or below 4 ° C (no more than 2 weeks)

Shelf life

emuls.d / inf. : 3 and

Directory → Gematotropona funds → Substitutes plasma, and other blood components → Perftoran