Polyhydroxiethyl starch

Chemical name

Др consisting of amilopectina, with a molecular mass 150000-450000 (around 264,000).

Characteristics

Available in the form of 10% sterile apirogennogo transparent, bledno-jeltogo (before chief) color solution (0.9% sodium chloride) for infusions (pH about 5.0).

Of drugs

The drugs-plazmozameshchatee. Long circulates in the blood line (kolloidoosmoticnosti) increases BCC contributes to the normalization and improvement of gemodinamicakih increases (support) AD accelerates Monday and facilitates the efficient collection of leukocyte estate in centrifugirovania to Leikafereza.molekula with molecular weight below 50,000 quickly eliminiruyutza by renal excretion. After a single on / in a dose of about 500 ml (about 50 g) with urine output 70-80% dose within 24 h, 5-6% dose spent on leikaferez remaining 12-15% (about 6.8 g) were slow off within one week.

Indications

Gipovolemia, hypovolaemic shock (prevention and treatment) : in case of burns, injuries, operations, septic conditions, etc.; Gemodilucia (including izovolemicescuu); The collection of leukocyte estate by centrifugation (as a further means to leikafereze).

Contraindications

Hypersensitivity, severe haemorrhagic diateza etc. Violations accompanied by bleeding, including in koagulopatiah, gipervolemia, gipergidratation or dehydration, severe long heart failure expressed by the human kidney with oligo- and anuriei (non-gipovolemiei), pregnancy, breast-feeding (at the end of treatment), children's age (up to 10 years).

Side-Effects

Allergic and anaphylactoidnye reaction, including hives, bronhospazm with breathing difficulties, swelling of the lungs, heart failure, raising amilazy in the serum; In the face of large doses koagulopatii (tranzitornaya carrying out the blood protrombinovogo and partial trombinovogo time), with gemodilucia reduction (within 24 h) of whey total protein albumin, calcium and fibrinoguena in leikafereze-headache and dizziness, diarrhea, nausea, vomiting, a temporary increase in body mass index, anxiety, insomnia, a sense of fatigue, weakness, malaise, fever, chills, drugs, oedema, parestesia, acne, pain in the chest, increased heart rates, a slight reduction in the number of platelets and haemoglobin levels.

Precautions

Be wary when using oteke lungs and congestive heart failure (due to fluid zirkulatonego krovenosny bed), and amended kidney Cl (as a major excretion-kidney), liver diseases in history (with multiple levels infuziah indirect cium in the serum normalizes through 96 h after the last injection). There is a need to take into account the likely drop whey values of protein, albumin, calcium, platelets, fibrinoguena, hemoglobin, raising amilazy (difficult diagnosis 06.04.2005), extension of the bleeding. Before and during the treatment recommended frequent and regular monitoring of blood, platelets, hemoglobin, gematokrita, creatinine, the protrombinovogo and partial tromboplastinovogo time. When temperatures oznoba and other complications during the leikafereza or instability detection solution infuziu immediately suspended. They should not impose solution to change color or education pretipitata crystalline.

Dosing and Administration

Dropped : in / with drip slowly; Introduction of the first 10 to 20 ml are under the control of Ballogo.pri gipovolemii - 250-500-1000 ml / day (up to 20 ml / kg / day). In gemodilucia-500 ml per day in the next few days; Total dose is not more than 5 litres; if necessary, the excess dose (in exceptional circumstances) of its share for a period of up to four weeks. The dosage, the duration and speed Infusion set individually in the light of the gravity and krovopoteri gipovolemii, gematokrita parameters. Recommended length Infusion is not less than 30 minutes in 500 ml (in the absence of extraordinary testimony). In leikafereze, 250-700 ml, thoroughly mixed with sodium zitratom (to stabilize antikoagulyatingo effect) imposed (subject to the normal rules of reimbursement) in centrifuzhny apparatus adding venous whole blood relative 1:8-1:13.

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