Gestrinone

Chemical name

(17альфа)-13-Этил-17-гидро кси-18,19-динорпрегна-4,9, 11-триен-20-ин-3-он

Gross

C21-H24-O2

Of drugs

The drugs-androgennoe, antiprogestagennoe, antiestrogennoe. Impact gonadotropina secretion, a gestagenov and estrogen. Absorbed quickly. The admission off 2.5 mg maximum content in plasma (19 µ g / ml) is achieved in 2 hours Continuous concentration of the drug at the time the application for 3 day. Not koumouliruet. T_1/2 is 27 hours Return with urine (40-45%) and faeces (35%). Reducing secreta gonadotropina expansion has been in the first month of treatment. This leads to atrophy Oxytocics and expressed clinical effect (a bleeding and pain) after one month. Affects ectopicescie implants outside the uterus.

Indications

Endometriosis, incl. oslojnenny infertility.

Restrictions on the use of

Diseases of the liver and kidney throm (incl. disease), metabolic disorders.

Contraindications

Acute heart failure, pregnancy, breast-feeding (should abandon breastfeeding).

Side-Effects

Tides blood to a person declines in the size of the mammary glands, the body mass index, krovanistye separated from the uterus (in the first week of treatment), headache, agitation sudorozhny syndrome, skin pigmentation, acne, seborrhea, gipertrihoz.

Specific guidance

If allowed to receive regular doses, it should be taken as soon as possible and then continue treatment on the scheme. If allowed to receive two or more doses, the treatment off and resume it in the first day of their menstrual cycle. During treatment should use effective contraception. For maximum effectiveness, it is necessary to strictly adhere to regimens.

Patient interaction

Rifampicin and anti drugs faster metabolism.

Precautions

Before starting therapy should be deleted pregnancy. Be wary appointed to migraines.

Dosing and Administration

Inside-2.5 mg in the 1st and 4th days of menstruation. In the future, continue to welcome the days twice a week for 2.5 mg for six months.

Directory → Hormones and their antagonists → Androgens, antiandrogena → Gestrinone