Methyltestosterone

Chemical name

(17beta) -17-gidroksi-17- metilandrost-4-en-3-on

Gross

C20-H30-O2

Characteristics

White or kremovato-bely powder or crystals gigroskopichen. Virtually nerastvorim in water, soluble in spirtah and organic solvents, poorly soluble in vegetable oils.

Of drugs

The drugs-androgennoe. Interacts with specific receptors zitoplazmaticescoy membrane on the surface of cells in organah-misheniah infiltrates the zitoplazmu the kernel causing activation genetic apparatus. Provides normal growth and development of male sex organs and secondary sexual characteristics : growth and activity secretornuu prostate, seed bubbles, penis, testicles, owolosenie podmyshechnykh and pubic areas thickening voice and brutalization vote, increases muscle mass and reduces fat deposition. The delay oxide, sodium carbonate, phosphate, reduces calcium excretion kidneys and contributes to its deposition in bone. Controls bone growth in length (pubertanetary period). Ingibiruet develop and release gipofizom LG and Fsg.pri ingestion rapidly absorbed. C_max achieved in 2 hours T_1/2 is 3-4 hours Biotransformiroetsa in the liver. Excreted kidneys, mainly in the form of metabolites (10% in an unmodified form).

Indications

Men : primary and gipogonadotropony gipogonadizm, feminnoe build and appearance boys have pubertatne age climax men; Women : neoperabelny breast cancer in postmenopauzne period in aftercare period after radical surgical interventions at the neoplasticeskih processes in the mammary gland in predmenopauzne period.

Contraindications

Tumor breast carcinoma of prostate cancer, pregnancy, pubertanetary age.

Side-Effects

Women : amenorea, symptoms virilization, girsutizm, ugreve skin; Men : ginekomastia and oligospermia; Oedema, diarrhoea phenomenon holetsaticeski hepatitis, gepatozellliarnaya carcinoma, gipercalziemia, increased bleeding, and changes in libido, headache, anxiety, depression, Generalized parestesia, giperlipidemia, allergic reactions.

Patient interaction

Do proximity effect anticoagulants, insulin. Androgennouu activity reduces barbiturates zimetidin, paratireoidin.

Dosing and Administration

For men dose is 40 mg once a day for 4-6 months. The highest daily dose is 100 mg. For women with tumors breast dose of 200 mg once a day (while carefully monitoring specialists).

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