Clomifene

Chemical name

2-[4-(2-Хлор-1,2-дифенилэт��нил)фенокси]-N,N-диэтил этанамин (in the form of citrate)

Gross

C26-H28-Cl-N-O

Characteristics

White or white with blue polka crystalline powder. It is soluble in water, sparingly soluble in alcohol.

Of drugs

The drugs-antiestrogennoe. Links estrogen receptors in the Hypothalamus and aicnikah. The ingestion adequately absorbed. Metabolised in the liver. Excreted with jelchew subjected enterogepaticescoy recycling. The organism appears to spread. T_1/2 at 5-7 days. In small doses enhances the secretion of hormones gonadotroponah (prolactin, and opened LG), stimulates ovulation. При низком содержании в организме эндогенных эстрогенов оказывает умеренный эстрогенный эффект, при высоком уровне - антиэстрогенный. Decreasing levels of circulating estrogen, helps gonadotropinov secreta. In high doses inhibits secretion gonadotropinov. Gestagenna and androgenna activity does not possess.

Indications

Anovulatornoe infertility (induction of ovulation), dysfunctional uterine bleeding, amenorea (disgonadotroponaya form secondary postcontrateptus) galactorea (in the face of pituitary tumors), polycystosis ovaries (syndrome Stein - Leventhal), Chiari syndrome - Frommel, androgennaya deficiency, oligospermia, for the diagnosis of gonadotropona pituitary function.

Pregnancy and lactation

Contraindicated in pregnancy.

Contraindications

Hypersensitivity, severe renal failure, uterine bleeding unclear etiology, ovarian cyst, tumour or inadequacy of the pituitary, pregnancy.

Side-Effects

Headache, dizziness, drowsiness, nausea, tides, the disorder, menorragia, diarrhoea, in the ovaries (incl. kistosnoe), pain at the bottom of the abdomen, increased body mass index, liver, allergic skin reactions. There is a growing probability of multiple pregnancy.

Specific guidance

Do not assign without the release of the persons whose professional activity requires quick physical and mental reactions (cause drowsiness). The treatment continued monitoring gynaecologist should check the ovaries, a vaginal studies watch something "maybe", etc.

Patient interaction

Compatible with drugs gonadotroponah hormones.

Overdosing

Nausea, vomiting, tides, the disorders. Symptoms of overdose quickly comes in the wake of abolition.

Dosing and Administration

Inside. To stimulate ovulation appoint 50 mg once a day, at night, from the 5th day of menstrual cycle within 5 days (in the absence of the cycle at any time); If there is no effect (owulyatsia does not happen within 30 days) increase the dose to 100 mg / day or a course lengthened to 10 days. Heading dose should not exceed 750 mg. The Caucus is determined by the availability of two-phase basal temperature, the average cycle of the source, the increase in the whey progesterone during the probable secondary phase luteinization or menstrual bleeding women amenoreei. If owulyatsia occurred, and the pregnancy is in the course must be repeated. If, after the moment no menstrual bleeding, it should take into account the possible pregnancy. Men appoint 50 mg 1-2 times a day for 3-4 months (a systematic monitoring spermatogramma).

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Clomifene