Estriol

Chemical name

(16альфа,17бета)-Эстра-1,3 ,5(10)-триен-3,16,17-триол (and in the form of succinate)

Gross

C18-H24-O3

Of drugs

Drugs, the mode. Is restore normal vaginal epithelium when atroficskih changes predmenopauzne and postmenopauzne periods normalizes vaginal pH environment, micro vagina, increases the resistance of the membrane to infectious and inflammatory processes that affect the quality and quantity of cervical fluid. Slight increases of plasma reduces cholesterol in the blood increases the circulation of Korticosteroidov.pri inwards and Local rapidly and completely absorbed, C_max achieved through one hour after taking into and after 1-2 h at intrawaginalnom application (value C_max after intrawaginalnogo application above). The blood contact albuminami (90%). Excretion are mainly kidneys; 2% return through the intestine in an unmodified form; Standing metabolites in urine begins in a few hours after the appointment and continued until 18 pm

Indications

Wasting mucous membrane divisions lower urinary tract caused estrogenna deficiency, pre - and post-treatment of women in postmenopauzne period when dealing vlagalischnam access, tides and increased sweating at night in menopause, infertility caused by zervikalnam factor despareunia, vaginal dryness, itching of the skin, frequent urination, the easy enuresis; Diagnosis unclear when results of the smear tests at zitologiu.

Contraindications

Thrombosis, embolism expressed by the human liver tumors gormonozawisimae uterus or breast, uterine bleeding unclear etiology, otoscleros, strong feature or holetsatical jaundice, as well as strengthening their expressions during the previous pregnancy or while receiving steroid drugs, pregnancy.

Side-Effects

Tension or pain in mammary glands whose fluid, nausea, hypersecretion of cervical mucus, arterial hypertension, convulsions gastrocnemius muscles, headache, visual impairment, pigment spots on the skin.

Precautions

Be wary when appoint thromboembolitic episodes in the history, heart failure, a human kidney, high blood pressure, epilepsy, migraine, severe liver diseases and endometriose, fibrosno-kistosna mastopatii, porfirii, гиперлипопротеинемии .

Dosing and Administration

Inside, the initial daily dose-4-8 mg once a day for two to three weeks, then dose gradually reduced to 1-2 mg / sut. Candles and vaginal cream : intrawaginalno 500 µ g / day daily in the first two weeks, then twice a week.

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Estriol