Estrone

Chemical name

3-Гидроксиэстра-1,3,5(10)т риен-17-он

Gross

C18-H22-O2

Characteristics

Small crystals white or white with blue polka crystalline powder. Virtually nerastvorim in water, soluble in alcohol, ether, acetone, dioxane, oils of vegetable origin.

Of drugs

Drugs, the mode. Besides the normal development of the female reproductive system and menstruation. Interfaces with zitoplazmaticakimi receptors in the sexual organs mammary glands, and Hypothalamus gipofize. It proliferatiou endometrium, stimulates development of the uterus, fallopian tubes, female secondary sexual characteristics, reduces climax disorder affects a skeleton tone and elasticity gained structures, change epifizah tubular bones. Decreases release gipofizarnah гонадотропинов.Метаб��лизм and inachtiwation conducted mainly in the liver (maloaktive metabolite is estriol), excreted in jelchew, in the gut reabsorbiruetsa and again enters the liver via the portal system.

Indications

Insufficient functions klimakterica dysfunction and gipoplasia ovaries, primary and secondary amenorea, postcastrationny syndrome, infertility, atroficski vaginitis, postmenopausny osteoporosis, cancer of the breast with metastasis, cancer prostate cancer (palliative measure), the secondary trochaic, diskinesia (induced by the admission of levodopa), Men gipersexualnosti with deviant sexual behaviour.

Restrictions on the use of

Epilepsy, migraine, kidney failure, depression, including in history, holetaz pregnant, circulatory failure, a breach of the liver, kidney disease gall bladder, gipercalziemia, trombofilicescie condition, childhood and adolescence (prior to the end of bone growth).

Contraindications

Hypersensitivity, malignant and benign tumours, mastopatia, Dysmenorrhea, vaginal and uterine bleeding unclear etiology, and throm retidivirute in pulmonary disease, pregnancy.

Side-Effects

Uterine bleeding, dismenorea, amenorea, предменструальноподо бный syndrome, increased mioma uterus, vaginal candidiasis, changes in cervical secretions, pain, increase and the allocation of the mammary glands, nausea, vomiting, pain spasticskie and pregnant abdomen, holetsatical jaundice, myocardial infarction, tromboembolia pulmonary artery throm, zistitopodobnyy syndrome, headaches, dizziness, depression, lack of folic acid deficiency megaloblastnaya et al. gipercalziemia (in patients with metstaticski defeat bones), oedema, hloazma, erythema (multiformnaya, uzlovataya), hemorrhagic skin, hair loss, girsutizm, changing face.

Patient interaction

Ampicillin, levomicetin tetracycline, neomycin, sulfanilamida reduce concentration in the blood (kishechno-pechenocnuu reduce circulation), ascorbic acid increases. Do effect tricyclic antidepressants (inachtiwatia down in the liver), glucocorticoids, hormones of the thyroid gland. Phenobarbital, rifampicin, etc. induktora monoxigenaz reduce estrogennouu activity.

Overdosing

There is nausea, uterine Krovotecheniami.lechenie : symptomatic.

Precautions

Treatment can be carried out only under careful medical supervision. In the long continuous appointment of high doses increases the risk of development of giperplasticeskih endometrium, and the preferable course interrupted by small doses in combination with gestagenami. In the case of pregnancy during treatment to the patient to explain the potential risk to the fetus.

Dosing and Administration

V / m. In substitution therapy, 0.1-1 mg per week, or one of a few techniques from 1 to 25 days of each month, with 7-10-dneve break, 2-3 rate. Senilny vaginitis, 0.1-0.5 mg 2-3 times a week for 3 weeks, followed by seven days. Dysfunctional uterine bleeding-2-5 mg daily (for a few days). Palliative treatment for 14800 prostate cancer from 2 to 4 mg three times a week for 3 months or more.

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Estrone