Ethisterone

Chemical name

(17альфа)-17-Гидроксипре гн-4-ен-20-ин-3-он

Gross

C21-H28-O2

Characteristics

White or white with a yellowish sheen crystalline powder. Virtually nerastvorim in water, very little is soluble in alcohol, soluble in oils.

Of drugs

The drugs-progestagennoe. As synthetic analogue of progesterone (5-6 times weaker) binds to a specific receptor on the surface of cells Organs will seep into the core and increases the synthesis of RNA. Does transition mucous membrane of the uterus coagulation phase into that secreta reduces airway and anxiety uterus and fallopian tubes, their sensitivity to oksitotino creates the necessary conditions for the development of oplodotvorennogo eggs in the uterus, promotes proliferation and secreta end divisions mammary glands, ingibiruet synthesis and the release of hormones luteinizirutego front of the pituitary. Not destroyed enzymes saliva and digestive tract, and can be applied enteralno and subilgvalno. After the intake is rapid biotransformation in the liver education and pregnandiola pregnenolona. Excreted kidneys.

Indications

Under yellow body, dysfunctional uterine bleeding, amenorea, disalgomenorea.

Contraindications

Hypersensitivity, tumors of the breast and genital organs, the liver and kidneys, incomplete abortion, krovanistye separated from the vagina, bronchial asthma, heart failure, epilepsy, migraine, diabetes, ectopic pregnancy, giperlipidemia, tromboflebita, embolic complications of cerebral circulation.

Side-Effects

Weakness, drowsiness, insomnia, diarrhoea phenomenon hepatitis, calkulezny holetsistit, impaired vision, embolic complications virilizm, increased body mass index, galactorea, krovanistye separated from the vagina, dismenorea, amenorea increase and compaction mammary glands, acne, alopecia, allergic reactions.

Patient interaction

Reduces effects antiagregantov, anticoagulants, bromokriptina.

Dosing and Administration

Assign 10-20 mg 2-3 times a day in the language, artistic methods to increase the dose to 60 mg. The highest single dose for adults-20 mg, the highest daily intake for adults is 60 mg.

Directory → Hormones and their antagonists → Estrogens, gestagena; Their homologues and antagonists → Ethisterone